New drug combo aims to shrink lung tumors before surgery in targeted trial

NCT ID NCT07229339

First seen Nov 17, 2025 · Last updated May 01, 2026 · Updated 21 times

Summary

This study tests whether adding the drug zipalertinib to standard chemotherapy can shrink tumors more effectively in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) before they have surgery. About 16 adults with stage II to IIIB cancer that can be removed will receive the combination, then have their tumor tissue checked after surgery. The goal is to see if the treatment reduces the amount of live cancer cells left in the tumor.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • UCLA / Jonsson Comprehensive Cancer Center

    Los Angeles, California, 90095, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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