New targeted pill shows promise for Hard-to-Treat lung cancers

NCT ID NCT05118789

Recruiting now Disease control Sponsor: Nuvalent Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called zidesamtinib (NVL-520) for people with advanced lung cancer or other solid tumors that have a specific genetic change (ROS1-positive). The goal is to find the best dose and see how well it shrinks tumors. About 359 adults will take part in two phases: first to check safety, then to measure effectiveness.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED SOLID TUMOR METASTATIC SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Atrium Health Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
CHU de Nantes
RECRUITING

Nantes, 44000, France
Centre Legon Berard
RECRUITING

Lyon, 69008, France
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan
Claudius Regaud Institute
RECRUITING

Toulouse, 31300, France
Cologne University Hospital
RECRUITING

Cologne, Germany
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Gregorio Marañón Hospital
RECRUITING

Madrid, 28007, Spain
Henry Ford Cancer Institute
RECRUITING

Detroit, Michigan, 48202, United States
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
IRCCS Istituto Tumori Giovanni Paolo II
RECRUITING

Bari, 70124, Italy
Institute Gustave Roussy
RECRUITING

Villejuif, 94805, France
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Nazionale Tumori Regina Elena
RECRUITING

Rome, 00128, Italy
Istituto Oncologico Veneto
RECRUITING

Padova, 35128, Italy
Kanagawa Cancer Center
RECRUITING

Kanagawa, 241-8515, Japan
Kindai University Hospital
RECRUITING

Osaka, 577-8502, Japan
MD Anderson Cancer Center
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Mass General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
NEXT Oncology - Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
National Cancer Center
RECRUITING

Gyeonggi-do, 10408, South Korea
National Cancer Center Hospital
RECRUITING

Tokyo, 104-0045, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
National Cheng Kung University Hospital
RECRUITING

Tainan, 70403, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
National University Hospital Singapore
RECRUITING

Singapore, 119074, Singapore
Netherlands Cancer Institute
RECRUITING

Amsterdam, 1066, Netherlands
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, 48121, Italy
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia
Princess Margaret Cancer Research
RECRUITING

Toronto, Ontario, M5GG 1L7, Canada
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Shizuoka Cancer Center
RECRUITING

Shizuoka, 411-8777, Japan
Stanford Medicine
RECRUITING

Palo Alto, California, 94305, United States
The Cancer Institute Hospital Of JFCR
RECRUITING

Tokyo, 135-8550, Japan
UC Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
UCI Medical Center
RECRUITING

Orange, California, 92868, United States
UOMI Cancer Center - Clinica Tres Torres
RECRUITING

Barcelona, 08017, Spain
University Hospital Leuven
RECRUITING

Leuven, 3000, Belgium
University Hospital of A Coruña
RECRUITING

A Coruña, 15006, Spain
University Medical Centre Groningen
RECRUITING

Groningen, Netherlands
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado Cancer Center
RECRUITING

Denver, Colorado, 80045, United States
University of Miami
RECRUITING

Coral Gables, Florida, 33146, United States
University of Washington / Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Università Politecnica Marche
RECRUITING

Ancona, 60121, Italy
Vall d'Hebron University Hospital
RECRUITING

Barcelona, 08035, Spain
Wakayama Medical University Hospital
RECRUITING

Wakayama, 641-8510, Japan
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea

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