Sex and DNA may change how your body handles this supplement
NCT ID NCT06939608
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at how quickly the body breaks down yohimbine, a dietary supplement, in 36 healthy adults aged 18 to 40. Researchers compared men and women with different versions of the CYP2D6 gene, which affects drug metabolism. Participants took a single low dose of yohimbine and had blood samples taken over 24 hours. The goal was to see if sex and genetics influence yohimbine levels, which could help personalize future drug dosing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- yohimbine
- What this could lead to
- If successful, this could help doctors predict how individuals process certain drugs based on sex and genetics, leading to more personalized dosing.
- What could go wrong
- This is a small, early-stage study in healthy volunteers, not a treatment trial. Results may not apply to people with medical conditions or those taking other medications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University Medicine Greifswald, Institute of Pharmacology
Greifswald, Mecklenburg-Vorpommern, 17489, Germany
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