New drug YL201 enters human trials for Hard-to-Treat cancers

NCT ID NCT05434234

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a new drug called YL201 in people with advanced solid tumors that have stopped responding to standard treatments. The trial has two parts: first, finding a safe dose, then testing that dose in more patients with specific cancer types. YL201 is given by IV every three weeks, sometimes combined with another cancer drug called atezolizumab. The goal is to see if it is safe and can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

YL201 (a drug given by IV infusion every 3 weeks, alone or with atezolizumab)

What this could lead to

If successful, this could lead to a new treatment option for people with advanced solid tumors that have not responded to other therapies.

What could go wrong

This is an early, first-in-human study, so safety and effectiveness are not yet known. The drug may cause side effects or not shrink tumors as hoped.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

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Locations

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    RECRUITING

    La Jolla, California, 92093-0698, United States

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    Fair Oaks, California, 95628, United States

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    Lone Tree, Colorado, 80124, United States

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    Washington D.C., District of Columbia, 20007, United States

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    Boston, Massachusetts, 02114, United States

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    Ann Arbor, Michigan, 48109, United States

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    Detroit, Michigan, 48292, United States

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    St Louis, Missouri, 63110, United States

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    Santa Fe, New Mexico, 87505-699, United States

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    New York, New York, 10029, United States

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    Chapel Hill, North Carolina, 27514, United States

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    Nashville, Tennessee, 37203, United States

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    San Antonio, Texas, 78229, United States

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    Houston, Texas, 77030, United States

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    Irving, Texas, 75039, United States

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    Tyler, Texas, 75701, United States

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    Fairfax, Virginia, 22031, United States

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    Spokane, Washington, 99208, United States

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    Tacoma, Washington, 98405, United States

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    Edmonton, Alberta, T6G 1Z2, Canada

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    Kelowna, British Columbia, V1Y 1E2, Canada

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    Brampton, Ontario, L6R 3J7, Canada

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    Toronto, Ontario, M5G 2C4, Canada

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    COMPLETED

    Guangzhou, Guangdong, 510000, China

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    Zhengzhou, Henan, 450003, China

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    Bordeaux, 33000, France

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    Dijon, 21000, France

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    Marseille, 13005, France

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    Nantes, 44093, France

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    Paris, 75248, France

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    Poitiers, 86021, France

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    Saint-Herblain, 44800, France

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    Suresnes, 92150, France

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    Barcelona, Barcelona, 08023, Spain

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    Barcelona, Barcelona, 08025, Spain

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    Madrid, Madrid, 28050, Spain

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    Madrid, Madrid, 28034, Spain

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    Moncloa-Aravaca, Madrid, 28040, Spain

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    Leganés, Madrid, 28911, Spain

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    Pamplona, Navarre, 31008, Spain

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    Pozuelo de Alarcón, Madrid, 28223, Spain

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    Usera, Madrid, 28041, Spain

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    Valencia, Valencia, 46010, Spain

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    RECRUITING

    Otwock, 05-400, Poland

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    NOT_YET_RECRUITING

    Poznan, 60-569, Poland

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