New epilepsy drug shows promise in reducing seizures

NCT ID NCT05614063

Completed Disease control Sponsor: Xenon Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a new drug called XEN1101 to existing medications could help reduce the frequency of focal seizures in adults with epilepsy. About 380 participants, who were already taking 1 to 3 seizure medications, received either XEN1101 or a placebo pill daily for 12 weeks. The main goal was to see if XEN1101 was safe and more effective than the placebo at lowering the number of seizures people experienced.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

ANESC Research

El Paso, Texas, 79912, United States
American Hospital Network LLC

Tbilisi, 0121, Georgia
Anschutz Health Sciences

Aurora, Colorado, 80011, United States
Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Austin Epilepsy Care Center (AECC)

Austin, Texas, 78758, United States
Austin Health Pharmacy Clinical Trials

Heidelberg, Victoria, 3079, Australia
Azienda Ospedaliero Universitaria Pisana

Pisa, 56100, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I

Rome, 00186, Italy
Beaumont Hospital

Dublin, D09 YD60, Ireland
Bluegrass Epilepsy Research, LLC

Lexington, Kentucky, 40504, United States
Brain Science Research Institute

Los Angeles, California, 90025, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CENyR

Caba, C1424, Argentina
Carilion Clinic - Neurology

Roanoke, Virginia, 24013, United States
Center For Neurologic Research

Lethbridge, Alberta, T1J 0N9, Canada
Centro Hospitalar de Entre o Douro e Vouga

Santa Maria da Feira, 4520-220, Portugal
Centro de investigación Clinica UC

Santiago, 833073, Chile
Centrum Medyczne Neuromed

Bydgoszcz, 85-163, Poland
Clinical Trials, Inc

Little Rock, Arkansas, 72205, United States
Consultants in Epilepsy and Neurology

Boise, Idaho, 83702, United States
Cornwell Health

Grand Rapids, Michigan, 49506, United States
Dent Neurosciences Research Center

Buffalo, New York, 14226, United States
Duke Neurology

Durham, North Carolina, 27713, United States
Emory Brain Health Center

Atlanta, Georgia, 30329, United States
Encore Medical Research of Weston, LLC

Weston, Florida, 33021, United States
Epilepsiezentrum Frankfurt Rhein-Main

Frankfurt, 60528, Germany
Epilepsy Center Bethel

Bielefeld, 33617, Germany
FORBELI s.r.o., Neurologicka ambulance

Prague, 160-00, Czechia
Hawaii Pacific Neuroscience

Honolulu, Hawaii, 96817, United States
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Clínico Universitario Valladolid

Valladolid, 47003, Spain
Hospital Clínico Vina del Mar

Viña del Mar, 2520612, Chile
Hospital Córdoba

Córdoba, CP 5000, Argentina
Hospital De Alta Complejidad en Red el Cruce Nestor Kirchner - SAMIC

Buenos Aires, B1888AAE, Argentina
Hospital General de Agudos J.M. Ramos Mejia

Buenos Aires, 1221, Argentina
Hospital Italiano

Buenos Aires, C1199ABB, Argentina
Hospital Pedro Hispano

Porto, 4464-513, Portugal
Hospital Ramón y Cajal

Madrid, 28034, Spain
Hospital Regional De Malaga

Málaga, 29010, Spain
Hospital Ruber Internacional

Madrid, 28034, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario y Politecnico La Fe

Valencia, 46026, Spain
Hospital Vithas La Milagrosa

Madrid, 28034, Spain
Human Science Research Trials S. de R.L. de C.V.

Mexico City, 14050, Mexico
IIS-Fundacion Jimenez Diaz/Farmacia

Madrid, 28040, Spain
INECO and Favoloro Fundation

Buenos Aires, 1060, Argentina
Indiana University, IU Health Partners, Adult Neurology Clinic

Indianapolis, Indiana, 46202, United States
Institute of Neurology and Neuropsychology

Tbilisi, 0186, Georgia
Istituto delle Scienze Neurologiche di Bologna

Bologna, 40139, Italy
John Radcliffe Hospital

Oxford, OX3 9DU, United Kingdom
LMU Munich, Department of Neurology

Munich, 81277, Germany
Le Centre Hospitalier de l'Universite' de Montreal (CHUM)

Montreal, Quebec, H2X3E4, Canada
Leeds Teaching Hospitals NHS Trust

Leeds, LS1 3EX, United Kingdom
London Health Sciences Centre

London, Ontario, N6A 5A5, Canada
MHAT Puls AD

Blagoevgrad, 2700, Bulgaria
MaineHealth Neurology - Scarborough

Scarborough, Maine, 04074, United States
MedStar Georgetown University Hospital

Clinton, Maryland, 20735, United States
Medsol Clinical Research Center

Port Charlotte, Florida, 33952, United States
Medstar Franklin Square Medical Center

Baltimore, Maryland, 21237, United States
Meridian Clinical Research, LLC

Raleigh, North Carolina, 27607, United States
Michigan State University

East Lansing, Michigan, 48824, United States
Mid-Atlantic Epilepsy and Sleep Center

Bethesda, Maryland, 20817, United States
Minneapolis Clinic of Neurology

Burnsville, Minnesota, 55337, United States
Montefiore Medical Center

The Bronx, New York, 10467-2401, United States
Mount Sinai Medical Center

New York, New York, 10029, United States
NYU Comprehensive Epilepsy Center (CEC)

New York, New York, 10016, United States
NZOZ Novo-Med

Katowice, 40-650, Poland
Neurocencias Esudios Clinicos SC

Sinaloa, 80020, Mexico
Neurosphera Sp. z o.o.

Warsaw, 02-829, Poland
Northeast Epilepsy Group

Hackensack, New Jersey, 07601, United States
Northern Care Alliance NHS Foundation Trust, Salford Care Organisation

Salford, M6 8HD, United Kingdom
Onsite Clinical Solutions, LLC

Charlotte, North Carolina, 28211, United States
Panhandle Research & Medical Clinic

Pensacola, Florida, 32503, United States
Pauls Stradina Clinical university hospital

Riga, LV-1002, Latvia
Philipps-Universität Marburg

Marburg, 35043, Germany
Prince of Wales Hospital

Sydney, New South Wales, 2031, Australia
Providence Brain & Spine Institute

Portland, Oregon, 97225, United States
Research Institute of Orlando, LLC

Orlando, Florida, 32806, United States
Riga East University Hospital

Riga, LV-1024, Latvia
Royal London Hospital for Integrated Medicine

London, WC1N 3HR, United Kingdom
Royal Prince Alfred Hospital (RAPH)

Camperdown, New South Wales, 2050, Australia
STAT Research S.A.

Buenos Aires, C1023AAB, Argentina
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Saint Louis University Medical School - Neurosciences Clinical Research Unit

St Louis, Missouri, 63104, United States
Sanatorio del Sur S.A.

San Miguel de Tucumán, 4000, Argentina
Sentara Neurology Specialists

Virginia Beach, Virginia, 23456, United States
Serenity Research

Miami, Florida, 33176, United States
Southern Neurology

Sydney, New South Wales, 2217, Australia
St Vincent's Hospital Melbourne

Fitzroy, Melbourne, 3065, Australia
St. George's Hospital NHS Foundation Trust

London, SW17 0QT, United Kingdom
Strada Patient Care Center

Mobile, Alabama, 36604, United States
Summa Health

Akron, Ohio, 44304, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140-4105, United States
The Alfred Hospital (Alfred Health)

Melbourne, Victoria, 3004, Australia
The Royal Melbourne Hospital

Melbourne, 3052, Australia
The University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
The University of Queensland (UQ) - Mater Research Institute (MRI)

Brisbane, Queensland, 4101, Australia
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Twoja Przychodnia NCM

Nowa Sól, 67-100, Poland
UMass Memorial Medical Center

Worcester, Massachusetts, 01655, United States
UT Health San Antonio

San Antonio, Texas, 78229, United States
UT Physicians Epilepsy Clinic

Houston, Texas, 77030, United States
Unidade Local de Saúde de São João

Porto, 4200-450, Portugal
Unitat d'Assaigs Clínics. Servei de Farmàcia

Barcelona, 08036, Spain
Universitatsklinik fur neurologie, universitats - und Rehabilitationskliniken Ulm

Ulm, 89081, Germany
Universitatsklinikum Bonn

Bonn, Germany
University Hospital of Wales

Cardiff, CF144XW, United Kingdom
University Hospitals Birmingham NHS Foundation Trust

Birmingham, B152GW, United Kingdom
University Medical Center Freiburg

Freiburg im Breisgau, 79106, Germany
University of Arizona, Health Sciences Center

Tucson, Arizona, 85724, United States
University of Auckland

Auckland, 1023, New Zealand
University of California, David Clinical & Translational Science Center Clinical Research (CCRC)

Sacramento, California, 95817, United States
University of Kentucky, Dept. of Neurology

Lexington, Kentucky, 40536-0284, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of South Florida

Tampa, Florida, 33606, United States
University of Washington Main Hospital

Seattle, Washington, 98104, United States
Università Degli Studi Gabriele d'Annunzio Di Chieti

Pescara, 66100, Italy
Universitätsklinikum Tübingen

Tübingen, 72076, Germany
Waikato Hospital

Hamilton, 3204, New Zealand
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
Washington University, St. Louis

St Louis, Missouri, 63110, United States
Weill Cornell Medicine/ New York-Presbyterian Hospital

New York, New York, 10021, United States
Westmead Hospital

Westmead, New South Wales, 2145, Australia
Xenoscience

Phoenix, Arizona, 85004, United States

Conditions

Explore the condition pages connected to this study.

FOCAL ONSET SEIZURES