Donor CAR-T cells take on aggressive t-cell leukemia in early trial

NCT ID NCT04984356

Completed Disease control Sponsor: Wugen, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested a new treatment called WU-CART-007 for people with T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma that came back or didn't respond to standard therapy. The treatment uses immune cells from a healthy donor that are specially designed to find and attack cancer cells. The main goals were to check safety and find the best dose in 28 participants.

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Conditions

The condition(s) this trial relates to.

lymphoblastic lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T-cell acute lymphoblastic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOBLASTIC LYMPHOMA T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Contacts and locations

Locations

Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
City of Hope

Duarte, California, 91010, United States
Erasmus MC

Rotterdam, Netherlands
Hospital Saint- Louis

Paris, France
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia
Prinses Maxima Centrum

Utrecht, Netherlands
University Hospital Robert Debre

Paris, France
University of Wisconsin

Madison, Wisconsin, 53792, United States
Vanderbilt University

Nashville, Tennessee, 37212, United States
Washington University

St Louis, Missouri, 63110, United States

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