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Why do women get chest pain without blocked arteries? a new registry aims to find out

NCT ID NCT07802457

Knowledge-focused Sponsor: NHS Greater Glasgow and Clyde Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study builds a registry of 400 women who have angina, or chest pain, even though their coronary arteries are not blocked. Doctors call this condition ANOCA, and it is more common in women than men, yet it has been under-studied. The registry will categorize different subtypes of ANOCA, track women's health over time through remote questionnaires, and offer opportunities to join future treatment trials. The goal is to understand the biological causes of angina in women and improve how it is diagnosed and managed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this registry succeeds, it could reveal why women develop angina without blocked arteries and point toward targeted treatments for this under-recognized condition.
What could go wrong
This is an observational registry, not a treatment trial, so it cannot prove what works. Data collection relies on patient reports and remote follow-up, which may have gaps.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include women of biological female sex with ANOCA and the participants should have a diagnosis of microvascular angina and/or vasospastic angina and an endotype defined by recent diagnostic tests within one year of enrolment.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ANOCA endotype0 * Myocardial perfusion reserve or coronary flow reserve recorded within one year * Seattle Angina Questionnaire frequency score \<100 * Female sex Exclusion Criteria: * Age \<18 years * Unable to provide informed consent * Unable to comply with the protocol

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Conditions

The condition(s) this trial relates to.

Angina Pectoris cardiovascular disorder nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Angina with no obstructive coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Brompton Hospital

    London, United Kingdom

  • Essex cardiothoracic centre

    Basildon, United Kingdom

  • Freeman Hospital

    Newcastle upon Tyne, United Kingdom

  • Guys and St Thomas Hospital

    London, United Kingdom

  • Kings college london

    London, United Kingdom

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Nottingham City Hospital

    Nottingham, United Kingdom

  • Queen Elizabeth University Hospital Clinical Research Facility,

    Glasgow, G51 4TF, United Kingdom

  • Royal Papworth Hospital

    Cambridge, United Kingdom

  • Royal United Hospital Bath

    Bath, United Kingdom

  • Sunderland Royal Hospital

    Sunderland, United Kingdom