Can weight management plus hormones reverse precancerous uterine changes and preserve fertility?
NCT ID NCT05316493
First seen Jun 06, 2026
Summary
This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management program including diet and exercise guidance. The goal is to see if this combination can reverse the abnormal cells and allow women to later become pregnant.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Obstetrics and Gynecology Hospital of Fudan University
RECRUITINGShanghai, China
Contact Phone: •••-•••-••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
levonorgestrel intrauterine system (Mirena) or megestrol acetate oral tablet
What this could lead to
If successful, this approach could help obese women with precancerous endometrial changes avoid hysterectomy and preserve their ability to have children.
What could go wrong
This is an early-phase study with no placebo group, so results may not be definitive. The treatments have side effects, and not all participants will respond or achieve pregnancy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.