Weekly HIV pill could replace daily dosing

NCT ID NCT06544733

Ongoing Disease control Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new once-weekly oral combination of two experimental drugs, lepetegravir and lenacapavir pacfosacil, can keep HIV under control as well as the daily pill Biktarvy. About 675 adults with already-suppressed HIV will take either the weekly combo or continue Biktarvy. The goal is to see if the weekly option is safe and effective at maintaining viral suppression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lepetegravir (GS-1720) and lenacapavir pacfosacil (GS-4182) combination
What this could lead to: If successful, this could offer people with HIV a convenient once-weekly pill option instead of daily medication, potentially improving adherence and quality of life.
What could go wrong: This is an early-to-mid stage trial (Phase 2/3) with 675 participants, so results may not confirm long-term safety or efficacy. There is also a risk that the weekly regimen may not suppress the virus as well as the daily standard of care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV-1-INFECTION

Contacts and locations

Locations

AIDS Healthcare Foundation - The Kinder Medical Group

Miami, Florida, 33133, United States
AXCES Research Group, LLC

Santa Fe, New Mexico, 87505, United States
AXCES Research Group, LLC

El Paso, Texas, 79902, United States
BIOS Clinical Research

Palm Springs, California, 92262, United States
Be Well Medical Center

Berkley, Michigan, 48072, United States
CAN Community Health

Fort Lauderdale, Florida, 33316, United States
CAN Community Health

Sarasota, Florida, 34237, United States
Central Texas Clinical Research

Austin, Texas, 78705, United States
Centro Ararat, Inc.

San Juan, PR, 00717, Puerto Rico
Chatham County Health Department

Savannah, Georgia, 31401, United States
Clinical Research Puerto Rico

San Juan, PR, 00909-1711, Puerto Rico
DCOL Center for Clinical Research

Longview, Texas, 75605, United States
Floridian Clinical Research

Miami Lakes, Florida, 33016, United States
Georgetown University Medical Center

Washington D.C., District of Columbia, 20007, United States
HOPE Clinical Research

San Juan, PR, 00909, Puerto Rico
KC CARE Health Center

Kansas City, Missouri, 64111, United States
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, California, 90502, United States
Mercer University, Department of Internal Medicine

Macon, Georgia, 31201, United States
Metro Infectious Disease Consultants, P.L.L.C.

Decatur, Georgia, 30033, United States
Midland Florida Clinical Research Center, LLC

DeLand, Florida, 32720, United States
Midway and Immunology Research Center

Ft. Pierce, Florida, 34982, United States
Mills Clinical Research

Los Angeles, California, 90069, United States
NYU Langone Health Vaccine Center

New York, New York, 10016, United States
NewYork-Presbyterian Queens

Flushing, New York, 11355, United States
North Texas Infectious Diseases Consultants, PA

Dallas, Texas, 75246, United States
Orlando Immunology Center

Orlando, Florida, 32803, United States
Pacific Oaks Medical Group

Beverly Hills, California, 90211, United States
Peter Shalit, MD

Seattle, Washington, 98104, United States
Prism Health North Texas, Oak Cliff Health Center

Dallas, Texas, 75215, United States
Proyecto ACTC

San Juan, PR, 00935, Puerto Rico
Rosedale Health and Wellness

Huntersville, North Carolina, 28078, United States
Ruane Clinical Research Group

Los Angeles, California, 90036, United States
Saint Michael's Medical Center

Newark, New Jersey, 07102, United States
St Hope Foundation, Inc.

Bellaire, Texas, 77401, United States
Texas Centers for Infectious Disease Associates

Fort Worth, Texas, 76104, United States
The Crofoot Research Center, INC.

Houston, Texas, 77098, United States
Triple O Research Institute, P.A.

West Palm Beach, Florida, 33407, United States
UAB 1917 Research Clinic

Birmingham, Alabama, 35294, United States
UCSF Division of HIV, Infectious Diseases & Global Medicine

San Francisco, California, 94110, United States

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