Lung cancer trial aims to uncover secrets of drug resistance
NCT ID NCT03969823
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at why some lung cancers stop responding to the drug osimertinib. Researchers will analyze the genetic makeup of tumors from 148 patients with advanced EGFR-mutant lung cancer who take osimertinib as their first treatment. The goal is to identify resistance mechanisms and track safety and survival outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Osimertinib (Tagrisso)
What this could lead to
If successful, this could reveal new ways to overcome drug resistance, potentially leading to better treatments for EGFR-mutant lung cancer.
What could go wrong
This is an early-stage, single-arm study focused on understanding resistance, not proving a new treatment works. Results may not lead to immediate clinical changes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Borame Medical Center
Seoul, South Korea
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Seoul National University Bundang Hospital
Seongnam, South Korea
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Seoul National University Hospital
Seoul, South Korea