New combo aims to stop postpartum bleeding in bleeding disorder
NCT ID NCT04344860
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed phase 3 trial tested whether adding tranexamic acid to recombinant von Willebrand factor (rVWF) reduces postpartum hemorrhage better than rVWF alone in 20 pregnant women with von Willebrand disease. Participants received either the combination or rVWF alone at delivery. The main goal was to measure blood loss during and after childbirth. This study aims to improve bleeding control in a high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Recombinant von Willebrand factor (rVWF) and tranexamic acid
- What this could lead to
- If it works, this combination could offer a better way to prevent dangerous bleeding after childbirth in women with von Willebrand disease.
- What could go wrong
- This is a small, single-center trial with only 20 participants, so results may not apply to everyone. The added benefit of tranexamic acid over rVWF alone is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hemophilia Center of Western PA
Pittsburgh, Pennsylvania, 15213, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Which drug stops Post-Birth bleeding better? a Head-to-Head test
- Could a simple calcium injection prevent dangerous bleeding after childbirth?
- Blood-Clotting showdown: which device best guides bleeding care in High-Risk patients?
- Simple C-Section techniques could slash postpartum bleeding risk