Scientists test drug combo to attack tough lymphoma

NCT ID NCT00972478

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study tested adding a new drug called vorinostat to standard chemotherapy (R-CHOP) for people newly diagnosed with an advanced type of lymphoma called diffuse large B-cell lymphoma (DLBCL). The first goal was to find a safe dose of vorinostat to combine with chemo. The second goal was to see if this combination helped patients live longer without their cancer getting worse. Researchers also looked at how the treatment affected the body's cells and immune system.

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Contacts and locations

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Locations

Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
AdventHealth Hendersonville

Hendersonville, North Carolina, 28792, United States
AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States
AnMed Health Hospital

Anderson, South Carolina, 29621, United States
Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Associates In Womens Health

Wichita, Kansas, 67208, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Cancer Care Center at Island Hospital

Anacortes, Washington, 98221, United States
Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States
Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States
Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States
Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States
Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States
Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States
Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States
Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States
Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States
Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905, United States
Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States
Cancer Research Consortium of West Michigan NCORP

Grand Rapids, Michigan, 49503, United States
Cancer Research for the Ozarks NCORP

Springfield, Missouri, 65804, United States
Castle Medical Center

Kailua, Hawaii, 96734, United States
Christus Saint Frances Cabrini Hospital

Alexandria, Louisiana, 71301, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Columbus NCI Community Oncology Research Program

Columbus, Ohio, 43215, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Dayton NCI Community Oncology Research Program

Dayton, Ohio, 45459, United States
DeSoto Regional Health System

Mansfield, Louisiana, 71052, United States
Doctors Hospital

Columbus, Ohio, 43228, United States
Evergreen Hematology and Oncology PS

Spokane, Washington, 99218, United States
Fairfield Medical Center

Lancaster, Ohio, 43130, United States
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Franciscan Saint Francis Health-Beech Grove

Beech Grove, Indiana, 46107, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Glacier Oncology PLLC

Kalispell, Montana, 59901, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Grady Memorial Hospital

Delaware, Ohio, 43015, United States
Grandview Hospital

Dayton, Ohio, 45405, United States
Grant Medical Center

Columbus, Ohio, 43215, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greene Memorial Hospital

Xenia, Ohio, 45385, United States
Harborview Medical Center

Seattle, Washington, 98104, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
HaysMed

Hays, Kansas, 67601, United States
Heartland Hematology and Oncology Associates Incorporated

Kansas City, Missouri, 64118, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Highland Clinic

Shreveport, Louisiana, 71105, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Hutchinson Regional Medical Center

Hutchinson, Kansas, 67502, United States
Interlakes Foundation Inc-Rochester

Rochester, New York, 14623, United States
Iredell Memorial Hospital

Statesville, North Carolina, 28677, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States
Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States
Kaiser Permanente Sacramento Medical Center

Sacramento, California, 95825, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente Washington

Seattle, Washington, 98112, United States
Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States
Kaiser Permanente-Fremont

Fremont, California, 94538, United States
Kaiser Permanente-Fresno

Fresno, California, 93720, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Redwood City

Redwood City, California, 94063, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-San Rafael

San Rafael, California, 94903, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Stockton

Stockton, California, 95210, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kansas City NCI Community Oncology Research Program

Prairie Village, Kansas, 66208, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Liberty Hospital

Liberty, Missouri, 64068, United States
Licking Memorial Hospital

Newark, Ohio, 43055, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791, United States
Marietta Memorial Hospital

Marietta, Ohio, 45750, United States
Mary Rutan Hospital

Bellefontaine, Ohio, 43311, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Menorah Medical Center

Overland Park, Kansas, 66209, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Minor and James Medical PLLC

Seattle, Washington, 98104, United States
Montana Cancer Consortium NCORP

Billings, Montana, 59102, United States
Montana Cancer Specialists

Missoula, Montana, 59802, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
NEA Baptist Memorial Hospital

Jonesboro, Arkansas, 72401, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, 72401, United States
North Kansas City Hospital

Kansas City, Missouri, 64116, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Ochsner LSU Health Monroe Medical Center

Monroe, Louisiana, 71202, United States
Overton Brooks Veteran's Administration Medical Center

Shreveport, Louisiana, 71101, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Providence Hospital

Mobile, Alabama, 36608, United States
Providence Medical Center

Kansas City, Kansas, 66112, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Reid Health

Richmond, Indiana, 47374, United States
Research Medical Center

Kansas City, Missouri, 64132, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rocky Mountain Oncology

Casper, Wyoming, 82609, United States
SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States
Saint Ann's Hospital

Westerville, Ohio, 43081, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Francis Hospital

Greenville, South Carolina, 29601, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint Joseph Health Center

Kansas City, Missouri, 64114, United States
Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086, United States
Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Saint Luke's South Hospital

Overland Park, Kansas, 66213, United States
Saint Michael Cancer Center

Silverdale, Washington, 98383, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Peter's Community Hospital

Helena, Montana, 59601, United States
Saint Rose Ambulatory and Surgery Center

Great Bend, Kansas, 67530, United States
Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Skagit Valley Hospital

Mount Vernon, Washington, 98274, United States
Southeast Clinical Oncology Research Consortium NCORP

Winston-Salem, North Carolina, 27104, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Spectrum Health Big Rapids Hospital

Big Rapids, Michigan, 49307, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Tripler Army Medical Center

Honolulu, Hawaii, 96859, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University Health Truman Medical Center

Kansas City, Missouri, 64108, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Rochester

Rochester, New York, 14642, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
Wenatchee Valley Hospital and Clinics

Wenatchee, Washington, 98801, United States
Wichita NCI Community Oncology Research Program

Wichita, Kansas, 67214, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States
Wright-Patterson Medical Center

Wright-Patterson Air Force Base, Ohio, 45433, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

ANN ARBOR STAGE II NON-HODGKIN LYMPHOMA ANN ARBOR STAGE III NON-HODGKIN LYMPHOMA ANN ARBOR STAGE IV NON-HODGKIN LYMPHOMA