New drug aims to keep brain tumors at bay after standard therapy
NCT ID NCT06809322
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether the drug vorasidenib can delay tumor progression in people with IDH-mutant grade 2 or 3 astrocytoma after they finish initial chemoradiotherapy. About 468 participants will receive either vorasidenib or a placebo daily. The main goal is to see if vorasidenib extends the time before the tumor grows back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vorasidenib
What this could lead to
If successful, vorasidenib could delay tumor regrowth after standard treatment, giving people with this brain cancer more time without progression.
What could go wrong
This is a phase 3 trial, but results are not yet known. The drug may not improve outcomes over placebo, and side effects could occur. It is not a cure.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AOU Citta della Salute e della Scienza di Torino
NOT_YET_RECRUITINGTorino, Italy
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Academisch Ziekenhuis Maastricht
RECRUITINGMaastricht, Netherlands
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Amsterdam UMC location VUMC
NOT_YET_RECRUITINGAmsterdam, Netherlands
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Assistance Publique Hopitaux de Paris APHP - Sorbonne
NOT_YET_RECRUITINGParis, France
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Bellaria Hospital, IRCCS Istituto delle Scienze Neurologiche - AUSL di Bologna
RECRUITINGBologna, Italy
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CHU Lyon - Hopital neurologique Pierre Wertheimer
RECRUITINGLyon, France
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Clatterbridge Cancer Centre
NOT_YET_RECRUITINGMetropolitan Borough of Wirral, United Kingdom
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Erasmus MC
RECRUITINGRotterdam, Netherlands
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Ghent University Hospital
RECRUITINGGhent, Belgium
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Spain
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Hospital de Sant Pau i La Santa Creu
RECRUITINGBarcelona, Spain
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Kepler University Hospital - Neuromed campus
RECRUITINGLinz, Austria
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Mannheim University Hospital
RECRUITINGMannheim, Germany
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Marseille APHM
NOT_YET_RECRUITINGMarseille, France
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Masaryk Memorial Cancer Institute
RECRUITINGBrno, Czechia
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Medical University of Innsbruck
NOT_YET_RECRUITINGInnsbruck, Austria
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Medical University of Vienna
RECRUITINGVienna, Austria
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NNeurology department heidelberg
RECRUITINGHeidelberg, Germany
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Oncopole Claudius Regaud, IUCT-Oncopole
NOT_YET_RECRUITINGToulouse, France
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Queen Elizabeth Hospital Birmingham
NOT_YET_RECRUITINGBirmingham, United Kingdom
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Royal Marsden Hospital
NOT_YET_RECRUITINGSurrey Quays, United Kingdom
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Sapienza University
NOT_YET_RECRUITINGRoma, Italy
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The Christie NHS Foundation Trust
NOT_YET_RECRUITINGManchester, United Kingdom
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U.Z. Leuven - Campus Gasthuisberg
RECRUITINGLeuven, Belgium
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Universitaetsklinikum Regensburg
RECRUITINGRegensburg, Germany
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Universitair Ziekenhuis Brussel
RECRUITINGBrussels, Belgium
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Universitary hospital Bordeaux France
NOT_YET_RECRUITINGBordeaux, France
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Universitaskliniken Bonn
RECRUITINGBonn, Germany
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University Hospital Basel
NOT_YET_RECRUITINGBasel, Switzerland
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University Hospital Frankfurt -Senckenberg Institute of Neurooncology
NOT_YET_RECRUITINGFrankfurt, Germany
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University Hospital Zurich
NOT_YET_RECRUITINGZurich, Switzerland
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Vall de Hebron Hospital
RECRUITINGBarcelona, Spain
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Veneto Institute of Oncology
NOT_YET_RECRUITINGPadova, Italy