New hope for advanced kidney cancer: Two-Drug combo tested in global trial

NCT ID NCT07000149

First seen Oct 31, 2025 · Last updated May 12, 2026 · Updated 23 times

Summary

This study tests whether a new drug called volrustomig, alone or combined with casdatifan, works better than the current standard treatment (nivolumab plus ipilimumab) for people with advanced clear cell kidney cancer. About 1,116 adults with advanced or metastatic kidney cancer that hasn't been treated before will take part. The goal is to see if the new combinations help people live longer or keep their cancer from growing.

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Contacts and locations

Locations

  • Research Site

    La Jolla, California, 92037, United States

  • Research Site

    Aurora, Colorado, 80045, United States

  • Research Site

    Boston, Massachusetts, 02215, United States

  • Research Site

    New York, New York, 10065, United States

  • Research Site

    Cleveland, Ohio, 44106, United States

  • Research Site

    Nashville, Tennessee, 37232, United States

  • Research Site

    Lubbock, Texas, 79430, United States

  • Research Site

    East Melbourne, 3002, Australia

  • Research Site

    Elizabeth Vale, 5112, Australia

  • Research Site

    North Adelaide, 5000, Australia

  • Research Site

    Syndey, 4032, Australia

  • Research Site

    Beijing, 100142, China

  • Research Site

    Guangzhou, 510060, China

  • Research Site

    Nanjing, 2100008, China

  • Research Site

    Nanning, 530021, China

  • Research Site

    Shanghai, 200032, China

  • Research Site

    Xiamen, 361003, China

  • Research Site

    Batumi, 6010, Georgia

  • Research Site

    Tbilisi, 0112, Georgia

  • Research Site

    Tbilisi, 0114, Georgia

  • Research Site

    Tbilisi, 0186, Georgia

  • Research Site

    Busan, 48108, South Korea

  • Research Site

    Seongnam-si, 13496, South Korea

  • Research Site

    Seongnam-si, 13620, South Korea

  • Research Site

    Seoul, 03080, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 06591, South Korea

  • Research Site

    Seoul, 5505, South Korea

  • Research Site

    Kaohsiung City, 833401, Taiwan

  • Research Site

    Taichung, 404327, Taiwan

  • Research Site

    Taichung, 40705, Taiwan

  • Research Site

    Tainan, 704, Taiwan

Conditions

Explore the condition pages connected to this study.