Spine graft study abandoned after only 6 patients

NCT ID NCT05614284

Terminated Disease control Sponsor: Orthofix Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to compare a man-made bone graft material called Virtuos against using the patient's own bone for lumbar spine fusion surgery in people with degenerative disc disease. The goal was to see if Virtuos could achieve similar fusion rates at 12 and 24 months. However, the trial was terminated early after enrolling only 6 participants, so no meaningful conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Virtuos Lyograft (bone graft substitute)
What this could lead to: If successful, this could show that Virtuos is as effective as using the patient's own bone for spinal fusion, potentially avoiding a second surgical site.
What could go wrong: The trial was terminated early with only 6 participants, so results are very limited and not reliable. It is unclear if Virtuos works as well as autograft.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE

Contacts and locations

Locations

Central CT Neurosurgery & Spine

New Britain, Connecticut, 06051, United States
Michigan Brain and Spine

Royal Oak, Michigan, 48073, United States
University of Texas South Western

Dallas, Texas, 75390, United States

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