New heart plug could replace blood thinners for AF patients
NCT ID NCT06707688
First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 26 times
Summary
This study tests a device called Amulet 2 that plugs a small pouch in the heart (the left atrial appendage) where clots often form in people with atrial fibrillation. The goal is to lower stroke risk without needing lifelong blood thinners. About 458 participants with AF and high stroke risk will receive the device and be followed for safety and effectiveness.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aarhus Universitetshospital
Aarhus, Denmark
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AdventHealth Orlando
Orlando, Florida, 32803, United States
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Arizona Arrhythmia Research Group
Phoenix, Arizona, 85016, United States
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Arrhythmia Research Group
Jonesboro, Arkansas, 72401, United States
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Baptist Medical Center
Jacksonville, Florida, 32207, United States
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Baylor Scott & White - The Heart Hospital Plano
Plano, Texas, 75093, United States
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Baylor Scott & White All Saints Medical Center
Fort Worth, Texas, 76104, United States
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CHI Health Creighton University Medical Center-Bergan Mercy
Omaha, Nebraska, 68124, United States
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CHU Gabriel Montpied
Clermont-Ferrand, Auvergn, France
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Cardioangiologisches Centrum am Bethanien Krankenhaus
Frankfurt am Main, Hesse, Germany
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Center Inselspital Bern
Bern, Switzerland
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Deutsches Herzzentrum der Charité
Berlin, Germany
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Heart Rhythm Associates
Shenandoah, Texas, 77380, United States
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Heinrich-Braun-Klinikum gemeinnützige gGmbH Standort Zwickau
Zwickau, Germany
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Henry Ford Providence Southfield Hospital
Southfield, Michigan, 48075, United States
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Hospital Clinico San Carlos
Madrid, Spain
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Hospital Clínic de Barcelona
Barcelona, Spain
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Hospital Universitario de Salamanca
Salamanca, Spain
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Hôpital Civil Marie Curie
Lodelinsart, Belgium
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Institut de Cardiologie de Montreal (Montreal Heart Inst.)
Montreal, Quebec, Canada
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Institute Cardio. Paris-Sud - Institut Jacques Cartier
Massy, France
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Kansas City Cardiac Arrhythmia Research Foundation
Overland Park, Kansas, 66211, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Mount Sinai Hospital
New York, New York, 10019, United States
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NYU Langone Health
New York, New York, 10016, United States
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Northside Hospital
Atlanta, Georgia, 30342, United States
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Ospedale San Raffaele
Milan, Italy
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Rigshospitalet
Copenhagen, Denmark
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Roper Hospital
Charleston, South Carolina, 29401, United States
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Texas Cardiac Arrhythmia
Austin, Texas, 78705, United States
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Trident Medical Center
Charleston, South Carolina, 29406, United States
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University of Ottawa Heart Institute
Ottawa, Ontario, K18 4W7, Canada
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Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Lübeck, Germany
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Vanderbilt Heart & Vascular Institute
Nashville, Tennessee, 37232, United States
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Vital Heart and Vein
Humble, Texas, 77338, United States
Conditions
Explore the condition pages connected to this study.