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Can a higher starting dose of vericiguat help heart failure patients faster?

NCT ID NCT06195930

Completed Symptom relief Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 06, 2026 · Updated 26 times

Summary

This study looked at whether people with chronic heart failure can safely start taking vericiguat at a 5 mg dose instead of the usual 2.5 mg. The goal is to reach the full 10 mg target dose more quickly. 106 participants took the 5 mg dose for 2 weeks, and researchers monitored side effects like low blood pressure and dizziness. The study was short and focused on safety, not long-term benefits.

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Contacts and locations

Locations

  • ASST Papa Giovanni XXIII

    Bergamo, Lombardy, 24127, Italy

  • ASST Spedali Civili di Brescia

    Brescia, Lombardy, 25123, Italy

  • Advanced Cardiovascular, LLC - Alexander City

    Alexander City, Alabama, 35010, United States

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229, United States

  • CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina

    CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina

  • Capio Citykliniken - Hjartmottagning

    Lund, 222 21, Sweden

  • Centro de Investigacion y Prevencion Cardiovascular | Sede Recoleta

    Buenos Aires, Ciudad Auton. de Buenos Aires, C1119ACN, Argentina

  • Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina

    Santa Fe, S3000FWO, Argentina

  • Centrum Medyczne Zdrowa

    Krakow, 31-216, Poland

  • Chear Center LLC

    New York, New York, 10455, United States

  • Clinical Best Solutions Sp. Z O.O. Sp.K.

    Lublin, 20-011, Poland

  • Clinical Best Solutions Sp. Z O.O. Sp.K.

    Warsaw, 00-710, Poland

  • Complex Rendelo Med Zrt.

    Székesfehérvár, 8000, Hungary

  • Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos

    Rosario, Santa Fe Province, S2000DEJ, Argentina

  • Coromed Smo Kft

    Pécs, 7623, Hungary

  • Eszak-Pesti Centrumkorhaz-Honvedkorhaz

    Budapest, 1134, Hungary

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, Lombardy, 27100, Italy

  • Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department

    Santiago de Compostela, A Coruña, 15706, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Ramon y Cajal | Cardiology - Research Unit

    Madrid, 28034, Spain

  • Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology Department

    Barcelona, 08907, Spain

  • Hospital del Mar | Cardiology Department

    Barcelona, 08003, Spain

  • Hospital la Paz

    Madrid, 28046, Spain

  • IRCCS Centro Cardiologico Monzino

    Milan, Lombardy, 20138, Italy

  • IRMED Osrodek Badan Klinicznych

    Piotrkow Trybunalski, 97-300, Poland

  • Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina

    Corrientes, 3400, Argentina

  • Karolinska Universitetssjukhuset

    Stockholm, 17176, Sweden

  • Malopolskie Centrum Sercowo-Naczyniowe PAKS

    Chrzanów, 32-500, Poland

  • NZOZ "Twoja Przychodnia" Sp. z o.o.

    Lublin, 20-857, Poland

  • Reid Physician Associates | Cardiology Department

    Richmond, Indiana, 47374, United States

  • Semmelweis Egyetem Belgyógyaszati és Haematológiai Klinika, Kardiológia

    Budapest, 1088, Hungary

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz

    Kaposvár, 7400, Hungary

  • St. Louis Heart & Vascular, PC

    St Louis, Missouri, 63136, United States

  • Tolna Varmegyei Balassa Janos Korhaz

    Szekszárd, 7100, Hungary

  • Vita Longa Sp. z o.o.

    Katowice, 40-748, Poland

Conditions

Explore the condition pages connected to this study.

CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION