New combo therapy shows promise for Treatment-Linked blood cancer

NCT ID NCT05379166

First seen Oct 31, 2025 · Last updated May 15, 2026 · Updated 37 times

Summary

This study tests whether combining two drugs, venetoclax and azacitidine, can help people with a type of blood cancer called therapy-related myelodysplastic syndrome (t-MDS), which develops after prior cancer treatment. About 33 adults with intermediate to very high risk t-MDS will receive the combination. The main goal is to see how many achieve complete remission, while also tracking side effects.

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Contacts and locations

Locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

Conditions

Explore the condition pages connected to this study.