New combo therapy shows promise for rare blood cancer
NCT ID NCT05379166
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial is testing whether combining venetoclax and azacitidine can help people with therapy-related myelodysplastic syndrome (t-MDS), a blood cancer that develops after prior cancer treatment. The study will enroll 33 adults and measure how many achieve complete remission. The goal is to find a more effective treatment for this difficult-to-treat condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
venetoclax and azacitidine
What this could lead to
If successful, this combination could offer a new treatment option for therapy-related myelodysplastic syndrome, potentially leading to higher remission rates.
What could go wrong
This is a small, early-phase trial with only 33 participants, so results may not apply to everyone. Side effects from the drugs are possible, and the treatment may not work for all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States