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Can an Antibiotic-Laced bone graft make dental implants more reliable?

NCT ID NCT07784075

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This trial tests whether adding the antibiotic vancomycin to a bone graft material improves the outcome of dental implants placed immediately after extracting a tooth with a chronic infection. Twenty people with badly decayed, hopeless teeth and periapical infection will receive the treatment. The study measures implant stability and bone changes around the implant to see if this combination reduces bone loss and improves healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A mixture of vancomycin (an antibiotic) with xenograft (bone graft material) applied during immediate dental implant placement
What this could lead to
If successful, this approach could improve the success and stability of dental implants placed in infected sockets, reducing complications and bone loss.
What could go wrong
This is a small early-phase trial, so results may not apply broadly. Adding antibiotics to grafts could carry risks like allergic reactions or interference with bone healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

20 people

The number who actually took part.

Started

Jul 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * a badly decayed, hopeless tooth with periapical infection indicated for extraction and seeking implant placement Exclusion Criteria: * Acute infected socket. * Any socket with more than four wall defects.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Immediate implant placement in chronic infected socket

Contacts and locations

Locations

  • Faculty of Dental Medicine,Al-Azhar University

    Asyut, 0000, Egypt