Early study checks if experimental drug vamorolone affects Body's salt balance

This completed Phase 1 trial tested whether the experimental drug vamorolone can block the mineralocorticoid receptor, which helps control salt and water balance in the body. Thirty healthy men received a single dose of vamorolone, a positive control drug (eplerenone), or no active drug, along with fludrocortisone to stimulate the receptor. Researchers measured sodium and potassium levels in urine to see if vamorolone blocks the receptor's effects.