Brain pacemaker tested for millions with untreatable depression

NCT ID NCT03887715

Recruiting now Disease control Sponsor: LivaNova Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a small, implanted device that gently stimulates a nerve in the neck can help people with severe depression that hasn't improved with standard treatments. About 6,800 participants will be randomly assigned to have the device turned on or left off for a year to compare results. The goal is to see if this 'vagus nerve stimulation' therapy can safely reduce depression symptoms and improve daily life for those who have run out of other options.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

AMR- Baber Research, Inc.
RECRUITING

Naperville, Illinois, 60563, United States

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APG Research, LLC
RECRUITING

Orlando, Florida, 32803, United States

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ATP Clinical Research, Inc.
RECRUITING

Costa Mesa, California, 92626, United States

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Access Multi Specialty Medical Clinic, Inc
TERMINATED

Burlingame, California, 94010, United States
Advanced Mental Health Care Inc.
RECRUITING

Royal Palm Beach, Florida, 33411, United States

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Advanced Research Institute, Inc.
TERMINATED

Indianapolis, Indiana, 56268, United States
Alivation Research, LLC
RECRUITING

Lincoln, Nebraska, 68526, United States

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Andrew Bishop, MD
TERMINATED

Jackson, Mississippi, 39216, United States
Barnes-Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States

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Beacon Medical Group Behavioral Health
ACTIVE_NOT_RECRUITING

South Bend, Indiana, 46601, United States
BioBehavioral Research of Austin
TERMINATED

Austin, Texas, 78759, United States
CMB Clinical Trials
WITHDRAWN

Colton, California, 92324, United States
Carilion Clinic
RECRUITING

Roanoke, Virginia, 24014, United States

Contact

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Center For Anxiety and Depression
RECRUITING

Mercer Island, Washington, 98040, United States

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Central Miami Medical Institute, LLC
WITHDRAWN

Miami, Florida, 33125, United States
Charak Center for Health and Wellness
RECRUITING

Garfield Heights, Ohio, 44125, United States

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Clinical Insights
WITHDRAWN

Glen Burnie, Maryland, 21061, United States
Clintex Research Group, Inc.
TERMINATED

Miami, Florida, 33135, United States
Dent Neurological Institute
RECRUITING

Amherst, New York, 14226, United States

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Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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Erie County Medical Center/State University of New York (SUNY) at Buffalo Affiliate
WITHDRAWN

Buffalo, New York, 14215, United States
Florida Behavioral Psych
RECRUITING

Largo, Florida, 33770, United States

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Florida Center for TMS
TERMINATED

Orlando, Florida, 32806, United States
Florida Center for TMS
RECRUITING

Saint Augustine, Florida, 94901, United States

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Galiz Research LLC
RECRUITING

Hialeah, Florida, 33016, United States

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Hapworth Research Inc.
RECRUITING

New York, New York, 10019, United States

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Healthy Perspective
RECRUITING

Nashua, New Hampshire, 03060, United States

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Houston Clinical Trials
TERMINATED

Houston, Texas, 77401, United States
IACT Health
WITHDRAWN

Grayson, Georgia, 30017, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States

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Jersey Shore University Medical Center
WITHDRAWN

Neptune City, New Jersey, 07753, United States
Joliet Center For Clinical Research
TERMINATED

Joliet, Illinois, 60435, United States
Kaizen Brain Center
RECRUITING

La Jolla, California, 92037, United States

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Keck Hospital of USC
RECRUITING

Los Angeles, California, 90033, United States

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ManuMind Interventional Psychiatry
RECRUITING

Woodbury, New York, 11797, United States

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Marshall University Joan C. Edwards School of Medicine
RECRUITING

Huntington, West Virginia, 25701, United States

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Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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Medical College of Georgia, Augusta University
RECRUITING

Augusta, Georgia, 30912, United States

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Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States

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Medycal Research, Inc
TERMINATED

Brooksville, Florida, 34609, United States
Michigan Clinical Research Institute PC
ACTIVE_NOT_RECRUITING

Ann Arbor, Michigan, 48105, United States
Millenia Psychiatry & Research, Inc
WITHDRAWN

Orlando, Florida, 32819, United States
Mindful Behavioral Health
RECRUITING

Boca Raton, Florida, 33431, United States

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Mindpath Care Centers
TERMINATED

Raleigh, North Carolina, 27606, United States
NPC Research
WITHDRAWN

Oklahoma City, Oklahoma, 73109-3834, United States
Neuropsychiatric Associates, Plc
TERMINATED

Woodstock, Vermont, 05091, United States
Neuroscience Research Institute
WITHDRAWN

Winfield, Illinois, 60910, United States
Neuroscience and TMS Treatment Center
RECRUITING

Brentwood, Tennessee, 37027, United States

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Northpointe Psychiatry
RECRUITING

Lewisville, Texas, 75057, United States

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Nova Psychiatry Inc.
RECRUITING

Orlando, Florida, 32803, United States

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Ocean Blue Medical Research Center
WITHDRAWN

Miami Springs, Florida, 33166, United States
PACT Atlanta LLC
TERMINATED

Decatur, Georgia, 30030, United States
Pearl Health Clinic
WITHDRAWN

Ammon, Idaho, 83406, United States
Precise Research Centers
RECRUITING

Flowood, Mississippi, 39232, United States

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Psych Atlanta
RECRUITING

Marietta, Georgia, 30060, United States

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PsychCare Consultants Research
RECRUITING

St Louis, Missouri, 63128, United States

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Psychiatric Care and Research
RECRUITING

O'Fallon, Missouri, 633668, United States

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Psychiatric Medicine Associates, LLC
RECRUITING

Skokie, Illinois, 60076, United States

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Psychiatric Specialty Center
TERMINATED

West Palm Beach, Florida, 33409, United States
Quantum Laboratories Inc.
TERMINATED

Pompano Beach, Florida, 33064, United States
Research Center Of Florida, Inc
WITHDRAWN

Miami, Florida, 33135, United States
Richmond Behavioral Associates
WITHDRAWN

Staten Island, New York, 10312, United States
Rise Clinical Research, LLC
TERMINATED

Missouri City, Texas, 77459, United States
Rivus Wellness & Research Institute
TERMINATED

Oklahoma City, Oklahoma, 73112, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States

Contact

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SF-CARE, Inc.
TERMINATED

San Rafael, California, 94901, United States
Scranton Medical Institutes
RECRUITING

Moosic, Pennsylvania, 18507, United States

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Seattle Neuropsychiatric Treatment Center
RECRUITING

Seattle, Washington, 98104, United States

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Segal Trials Corporate
WITHDRAWN

Lauderhill, Florida, 33319, United States
Sheppard Pratt Health System, Inc.
RECRUITING

Baltimore, Maryland, 21204, United States

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Signature Research Associates, Inc.
ACTIVE_NOT_RECRUITING

Fairlawn, Ohio, 44333, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62794, United States

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State University Of New York Upstate Medical University
TERMINATED

Syracuse, New York, 13210, United States
Stedman Clinical Trials
RECRUITING

Tampa, Florida, 33613, United States

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Stony Brook University Hospital
TERMINATED

Stony Brook, New York, 11794, United States
Sunrise Research Institute
TERMINATED

Boca Raton, Florida, 33325, United States
Syrentis Clinical Research
WITHDRAWN

Santa Ana, California, 92705, United States
Texas Tech University Health Science Center
RECRUITING

El Paso, Texas, 79905, United States

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The Center for Neuropsychiatry and Brain Stimulation (CNBS) ARC Health
TERMINATED

Cary, North Carolina, 27519, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States

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The University Of Texas Medical School At Houston - UT Center Of Excellence On Mood Disorders
RECRUITING

Houston, Texas, 77054, United States

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The University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States

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Trinity Medical
RECRUITING

Lewiston, New York, 14092, United States

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UAB Huntsville Regional Medical Center
RECRUITING

Huntsville, Alabama, 35801, United States

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UT Health Austin, Mulva Clinic for the Neurosciences
RECRUITING

Austin, Texas, 78712, United States

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University Hospitals Case Medical Center
WITHDRAWN

Cleveland, Ohio, 44106, United States
University Of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States

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University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States

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University of California San Diego
ACTIVE_NOT_RECRUITING

San Diego, California, 92103, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55416, United States

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University of Missouri
RECRUITING

Columbia, Missouri, 65212, United States

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University of New Mexico - Psychiatric Center
WITHDRAWN

Albuquerque, New Mexico, 87102, United States
University of Oklahoma School of Community Medicine
RECRUITING

Tulsa, Oklahoma, 74135, United States

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University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States

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University of Wisconsin
RECRUITING

Madison, Wisconsin, 53719, United States

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Wake Forest University Health Science
WITHDRAWN

Winston-Salem, North Carolina, 27103, United States
West Virginia Clinical and Translational Science Institute
WITHDRAWN

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

TREATMENT RESISTANT DEPRESSION