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Can Light-Treated implants and melatonin help dental implants hold better?

NCT ID NCT07853976

Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 02, 2026 · Last updated Oct 02, 2026

Summary

Researchers at Mansoura University are comparing three approaches to replacing missing teeth in the upper back jaw: dental implants treated with ultraviolet light, the same implants combined with melatonin, and standard implants. The upper back jaw often has softer bone, which can make implants less stable. The team will place 21 implants in adults and track stability and bone levels over time to see whether the UV treatment or melatonin makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultraviolet light treatment of the implant surface, with or without the hormone melatonin
What this could lead to
If it works, this could give dentists a way to help implants hold better in the upper back jaw, where bone quality is often poor.
What could go wrong
This is a small study of 21 implants, so any differences may be chance. Implants can still fail or lose surrounding bone, and melatonin's effect on human bone healing around implants is not established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 18 and 60 years old. * Patients seeking replacement of missed single or multiple teeth in the posterior maxilla. * Sufficient bone volume (height and width) to accommodate dental implant placement without major bone grafting. * Good oral hygiene and motivated patients. * Systemically healthy patients with no contraindications for minor oral surgery. Exclusion Criteria: * Patients with uncontrolled systemic diseases * Patients who received radiation therapy in the head and neck region within the last 5 years. * Heavy smokers (more than 10 cigarettes per day). * Patients with active periodontal disease or poor oral hygiene. * Pregnant or lactating females. * Parafunctional habits such as severe bruxism or clenching.

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Conditions

The condition(s) this trial relates to.

bone resorption disease Jaw, Edentulous, Partially

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone resorption Dental implant failure Jaw, edentulous, partially

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    RECRUITING

    Al Mansurah, Dakahlia Governorate, Egypt

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