New hope for Tough-to-Treat uterine cancer: trial tests promising drug duo

NCT ID NCT05432791

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is for people with advanced uterine leiomyosarcoma, a type of cancer, that has continued to grow despite at least two prior chemotherapy treatments. It compares a new combination of two oral drugs, olaparib and temozolomide, against the current standard chemotherapy options. The goal is to see if the new combination can better control the cancer's growth and help patients live longer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Beacon Kalamazoo Cancer Center

Kalamazoo, Michigan, 49009, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
City of Hope at Irvine Lennar

Irvine, California, 92618, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Contra Costa Regional Medical Center

Martinez, California, 94553-3156, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
ECU Health Medical Center

Greenville, North Carolina, 27834, United States
Epic Care Cyberknife Center

Walnut Creek, California, 94597, United States
Epic Care Partners in Cancer Care

Emeryville, California, 94608, United States
Epic Care-Dublin

Dublin, California, 94568, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Heartland Oncology and Hematology LLP

Council Bluffs, Iowa, 51503, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, 98684, United States
Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210, United States
Legacy Meridian Park Hospital

Tualatin, Oregon, 97062, United States
Legacy Mount Hood Medical Center

Gresham, Oregon, 97030, United States
Legacy Salmon Creek Hospital

Vancouver, Washington, 98686, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
McFarland Clinic - Boone

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oncology Associates PC

Omaha, Nebraska, 68114, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Our Lady of the Lake Medical Oncology

Baton Rouge, Louisiana, 70817, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care Center - Westerly

Westerly, Rhode Island, 02891, United States
Smilow Cancer Hospital Care Center at Glastonbury

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital Care Center at Long Ridge

Stamford, Connecticut, 06902, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital-Waterbury Care Center

Waterbury, Connecticut, 06708, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UH Seidman Cancer Center at UH Avon Health Center

Avon, Ohio, 44011, United States
UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States
Women and Infants Hospital

Providence, Rhode Island, 02905, United States
Yale University

New Haven, Connecticut, 06520, United States
Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473, United States

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED UTERINE CORPUS LEIOMYOSARCOMA METASTATIC UTERINE CORPUS LEIOMYOSARCOMA STAGE III UTERINE CORPUS LEIOMYOSARCOMA AJCC V8 STAGE IV UTERINE CORPUS LEIOMYOSARCOMA AJCC V8 UNRESECTABLE UTERINE CORPUS LEIOMYOSARCOMA