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Low-Carb paradox: study probes why some see blood sugar spike

NCT ID NCT07713316

Knowledge-focused Sponsor: Brigham Young University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study investigates why some people on low-carb diets experience unexpectedly high blood glucose. Researchers measure hormones like glucagon and insulin after participants drink carbohydrate, protein, or fat beverages. The goal is to understand how different nutrients affect blood sugar regulation in people who follow a low-carb diet.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
carbohydrate drink, fat drink, or protein drink
What this could lead to
If successful, this research could explain why some people on low-carb diets have higher blood sugar and help tailor dietary advice.
What could go wrong
This is a small, early-stage observational study with only 24 participants, so findings may not apply broadly. It does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

May 2021

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * weight stable (± 3% body weight) for the past 3 months * adhering to a low-carbohydrate (50g carbohydrates or less per day) diet at least 2 weeks prior to and during the duration of the one-month study Exclusion Criteria: * unwilling to provide written consent * diagnosed with chronic disease(s) including cardiac disease, cancer, or liver disease, * pregnant or lactating, * taking medications that alter metabolism, * allergies to latex, cow's milk/milk products, olives, chlorhexidine, or dextrose, * have had more than 5 x-rays in the past year.

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Conditions

The condition(s) this trial relates to.

hyperglycemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Elevated blood glucose Low-carbohydrate diet

Contacts and locations

Locations

  • Brigham Young University

    Provo, Utah, 84606, United States

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