New drug shows promise for Hard-to-Treat bowel disease

NCT ID NCT06049017

Summary

This study tested whether an experimental drug called JNJ-77242113 could help adults with moderate-to-severe ulcerative colitis who hadn't responded well to standard treatments. Researchers compared the drug against a placebo in 252 participants over 12 weeks to see if it reduced symptoms and inflammation. The main goal was to determine if the treatment was both safe and effective at controlling this chronic bowel condition.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ABP Research Services Corp.

    Oakville, Ontario, L6L 5L7, Canada

  • APHP - Hopital Bichat - Claude Bernard

    Paris, 75018, France

  • APHP - Hopital Henri Mondor

    Créteil, 94000, France

  • AZ Sint-Lucas

    Ghent, 9000, Belgium

  • Accurate Clinical Research, Inc.

    Humble, Texas, 77346, United States

  • Addenbrookes Hospital

    Cambridge, CB2 0QQ, United Kingdom

  • Amel Med LLC Research

    Georgetown, Texas, 78628, United States

  • Aoyama Naika Clinic

    Kobe, 650-0015, Japan

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Atlanta Gastroenterology Associates

    Atlanta, Georgia, 30342, United States

  • Atrium Health

    Charlotte, North Carolina, 28204, United States

  • Azienda Ospedaliera San Camillo - Roma

    Roma, 00152, Italy

  • BR TRIALS Ensaios Clinicos e Consultoria Ltda

    São Paulo, 01236030, Brazil

  • Barrie GI Associates

    Barrie, Ontario, L4M 7G1, Canada

  • Barts Health NHS Trust

    London, E11 1NR, United Kingdom

  • Blacktown Hospital

    Blacktown, 2148, Australia

  • Bodyclinic Sp. z o.o. sp. k

    Warsaw, 03 712, Poland

  • CDC - Centro Digestivo de Curitiba

    Curitiba, 80430-180, Brazil

  • CHRU Besancon Hopital Jean Minjoz

    Besançon, 25030, France

  • CHRU de Lille Hopital Claude Huriez

    Lille, 59037, France

  • CHU Nimes Hopital Caremeau

    Nîmes, 30900, France

  • CHU Saint Etienne Hopital Nord

    Saint-Priest-en-Jarez, 42270, France

  • CHU Saint-Pierre

    Brussels, 1000, Belgium

  • CHU Toulouse - Hopital de Rangueil

    Toulouse, 31400, France

  • CHU de Nancy_ Hopital Brabois

    Vandœuvre-lès-Nancy, 54500, France

  • CHU de Nice Hopital de l Archet

    Nice, 06202, France

  • CIPREC

    Buenos Aires, C1061AAS, Argentina

  • Caprock Gastro Research

    Lubbock, Texas, 79424, United States

  • Care Access Research, Ogden

    Ogden, Utah, 84403, United States

  • Casa Sollievo Della Sofferenza IRCCS

    San Giovanni Rotondo, 71013, Italy

  • Centralny Szpital Kliniczny Mswia

    Warsaw, 02 507, Poland

  • Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman

    Liège, 4000, Belgium

  • Centre Hospitalier de l'Universite de Montreal

    Montreal, Quebec, H2X 0C1, Canada

  • Centrul Medical Valahia

    Ploieşti, 100032, Romania

  • Centrum Medyczne Lukamed Spolka z Ograniczona Odpowiedzialnoscia

    Chojnice, 89-600, Poland

  • Centrum Medyczne Medis ManerMed Sp Z O O

    Bydgoszcz, 85 229, Poland

  • Centrum Medyczne Medyk

    Rzeszów, 35-326, Poland

  • Centrum Medyczne Oporow

    Wroclaw, 52 416, Poland

  • Centrum Medyczne Plejady

    Krakow, 30 363, Poland

  • Cer Instituto Medico

    Buenos Aires, B1878DVB, Argentina

  • Charlotte Gastroenterology and Hepatology, PLLC

    Charlotte, North Carolina, 28207, United States

  • Chongqing General Hospital

    Chongqing, 400014, China

  • Clinexpert Kft

    Gyöngyös, 3200, Hungary

  • Clinique Ambroise Pare

    Neuilly-sur-Seine, 92200, France

  • Clinnova Research

    Anaheim, California, 92805, United States

  • Concord Repatriation General Hospital

    Concord, 2139, Australia

  • Cotton O'Neil Digestive Health Center

    Topeka, Kansas, 66606, United States

  • DHAT Research Institute

    Garland, Texas, 75044, United States

  • Debreceni Egyetem Gasztroenterologiai Klinika

    Debrecen, 4032, Hungary

  • DiGiovanna Institute for Medical Education & Research

    North Massapequa, New York, 11758, United States

  • Digenio - Centrul Medical de Gastroenterologie, Hepatologie si Endoscopie Digestiva

    Cluj-Napoca, 400061, Romania

  • Digestive Disease Specialists Inc

    Oklahoma City, Oklahoma, 73112, United States

  • EMC Instytut Medyczny SA

    Wroclaw, 54 144, Poland

  • Ege Universitesi Tip Fakultesi

    Izmir, 35040, Turkey (Türkiye)

  • Endoscopic Research Inc

    Orlando, Florida, 32803-1853, United States

  • Eugastro GmbH

    Leipzig, 04103, Germany

  • Fairfield General Hospital

    Bury, Greater Manchester, United Kingdom

  • Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano

    Milan, 20122, Italy

  • Fondazione Policlinico Universitario A Gemelli IRCCS

    Roma, 00168, Italy

  • GASTROMED Sp. z o.o.

    Torun, 87 100, Poland

  • GCP Clinical Research

    Tampa, Florida, 33609, United States

  • Gastroenterologie, s.r.o., Hradec Kralove

    Hradec Kralova, 500 02, Czechia

  • Gastroenterologische Gemeinschaftspraxis Minden

    Minden, 32423, Germany

  • Gastroenterology Associates P.A.

    Greenville, South Carolina, 29607, United States

  • Gastroenterology Associates of Tidewater

    Chesapeake, Virginia, 23320, United States

  • Gastroenterology and Internal Medicine Research Institute (GIRI)

    Edmonton, Alberta, T5R 1W2, Canada

  • Gastroenterology of Southern Indiana

    New Albany, Indiana, 47150, United States

  • Gazi University Medical Faculty

    Ankara, 6500, Turkey (Türkiye)

  • Gedyt - Consultorios Gastroenterologia

    Buenos Aires, C1425, Argentina

  • Ghent University Hospital

    Ghent, 9000, Belgium

  • Govind Ballabh Pant Hospital

    New Delhi, 110002, India

  • Guys St Thomas Hospital

    London, SE1 7EH, United Kingdom

  • Hamamatsu University Hospital

    Hamamatsu, 431 3192, Japan

  • Hepato-gastroenterologie HK, s.r.o.

    Hradec Králové, 500 12, Czechia

  • Hoag Memorial Hospital

    Newport Beach, California, 92663, United States

  • Hosp. Alvaro Cunqueiro

    Vigo, 36312, Spain

  • Hosp. Arquitecto Marcide

    Ferrol, 15405, Spain

  • Hosp. Clinico Univ. de Santiago

    Santiago de Compostela, 15706, Spain

  • Hosp. Clinico Univ. de Valencia

    Valencia, 46010, Spain

  • Hosp. Ntra. Sra. de Valme

    Seville, 41014, Spain

  • Hosp. Univ. Fundacion Alcorcon

    Alcorcón, 28922, Spain

  • Hosp. Univ. I Politecni La Fe

    Valencia, 46026, Spain

  • Hosp. Univ. La Paz

    Madrid, 28046, Spain

  • Hosp. Univ. Pta. de Hierro Majadahonda

    Majadahonda, 28222, Spain

  • Hosp. Virgen Macarena

    Seville, 41009, Spain

  • Hosp. de Cabuenes

    Gijón, 33394, Spain

  • Hospices Civils de Lyon CHU Lyon Sud

    Pierre-Bénite, 69495, France

  • Hospital Provincial del Centenario

    Rosario, S2000KDS, Argentina

  • Hospital Sultanah Aminah

    Johor Bahru, 80100, Malaysia

  • Hospital de Clinicas de Porto Alegre - Hospital de Clinicas

    Porto Alegre, 90035 903, Brazil

  • I.H.S. Health. LLC

    Kissimmee, Florida, 34741, United States

  • INTEGRAL Pesquisa e Ensino

    Votuporanga, 15501-405, Brazil

  • ISCARE a.s.

    Prague, 19000, Czechia

  • Inje University Haeundae Paik Hospital

    Busan, 48108, South Korea

  • Instituto D Or de Pesquisa e Ensino

    São Paulo, 01401 002, Brazil

  • Istituto Clinico Humanitas

    Rozzano, 20089, Italy

  • Japanese Red Cross Osaka Hospital

    Osaka, 543 8555, Japan

  • Kagoshima IBD Gastroenterology Clinic

    Kagoshima, 892-0843, Japan

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Kings College Hospital

    London, SE5 9RS, United Kingdom

  • Kinshukai Infusion Clinic

    Osaka, 530-0011, Japan

  • Klinikum Augsburg

    Augsburg, D-86158, Germany

  • Krankenhaus Waldfriede Mitte

    Berlin, 14163, Germany

  • L2IP Instituto de Pesquisas Clinicas

    Brasília, 70.200-730, Brazil

  • Lanzhou University Second Hospital

    Lanzhou, 730031, China

  • London Health Sciences Centre

    London, Ontario, N6A 5A5, Canada

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Medical Associates Research Group, Inc.

    San Diego, California, 92123, United States

  • Medical Network Spolka z o.o. WIP Warsaw IBD Point Profesor Kierkus

    Warsaw, 04 501, Poland

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Melita Medical Sp. z o.o.

    Wroclaw, 53 611, Poland

  • Mercy Medical Center

    Baltimore, Maryland, 21202-2102, United States

  • Mersin University Medical Faculty

    Mersin, 33343, Turkey (Türkiye)

  • Midas Hospital

    Nagpur, 441108, India

  • Mie University Hospital

    Tsu, 514 8507, Japan

  • Nanjing Drum Tower Hospital

    Nanjing, 210008, China

  • National Hospital Organization Shizuoka Medical Center

    Shimizu, 411-8611, Japan

  • Nemocnice Ceske Budejovice

    České Budějovice, 370 01, Czechia

  • Nemocnice Slany

    Slaný, 27401, Czechia

  • New York Gastroenterology Associates

    New York, New York, 10075, United States

  • Northshore Gastroenterology Research, LLC

    Westlake, Ohio, 44145, United States

  • Ochsner Medical Center

    Jefferson, Louisiana, 70121, United States

  • Ospedale Sacro Cuore Don Calabria

    Negrar, 37024, Italy

  • Ospedale San Raffaele di Milano

    Milan, 20132, Italy

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, OX3 9DU, United Kingdom

  • Pannónia Magánorvosi Centrum Kft

    Budapest, H-1136, Hungary

  • Peak Gastroenterology Associates

    Colorado Springs, Colorado, 80907, United States

  • Pesquisare Saude

    Santo André, 09080-110, Brazil

  • Qilu Hospital of Shandong University

    Jinan, 250012, China

  • S C Delta Health Care S R L

    Bucharest, 014146, Romania

  • S. R. Kalla Memorial General Hospital

    Jaipur, 302006, India

  • SIDS Hospital & Research Centre

    Surat, 395002, India

  • Sai Gastroenterology Proctology

    Fujiidera-shi, 583-0027, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sanatorio 9 de Julio

    San Miguel de Tucumán, 4000, Argentina

  • Sapporo Higashi Tokushukai Hospital

    Sapporo, 065-0033, Japan

  • Sapporo Tokushukai Hospital

    Sapporo, 004-0041, Japan

  • Semmelweis Egyetem

    Budapest, 1083, Hungary

  • Semmelweis Egyetem

    Budapest, 1088, Hungary

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Shengjing Hospital Of China Medical University

    Shenyang, 110022, China

  • Sir Run Run Shaw Hospital Zhejiang University School of Medicine

    Hangzhou, 310000, China

  • Sonomed Sp. z o.o.

    Szczecin, 71-685, Poland

  • Southampton University Hospital

    Southampton, SO16 6YD, United Kingdom

  • Southern Star Research Institute, LLC

    San Antonio, Texas, 78229, United States

  • Spital Memorial

    Bucharest, 013823, Romania

  • St Georges University Hospital NHS Foundation Trust

    London, SW17 0RE, United Kingdom

  • Staedtisches Klinikum Lueneburg

    Lüneburg, 21339, Germany

  • Sultan Idris Shah Hospital

    Kajang, 43000, Malaysia

  • Sunshine Coast University Hospital

    Birtinya, 4575, Australia

  • Tandem Clinical Research

    Marrero, Louisiana, 70072, United States

  • The Catholic university of Korea, St. Vincent's Hospital

    Suwon, 16247, South Korea

  • The First Affiliated Hospital Sun Yat sen University

    Guangzhou, 510060, China

  • The Second Affiliated Hospital of Air Force Medical University - Tangdu Hospital

    Xi'an, 710038, China

  • The Sixth Affiliated Hospital Sun Yat sen University

    Guangzhou, 510655, China

  • The second Xiangya Hospital of Central South University

    Changsha, 410011, China

  • Toho University Sakura Medical Center

    Sakura, 285-8741, Japan

  • Tokyo Metropolitan Bokutoh Hospital

    Sumida Ku, 130 8575, Japan

  • Tsujinaka Hospital Kashiwanoha

    Kashiwa, 277-0871, Japan

  • Tyler Research Institute, LLC

    Tyler, Texas, 75701, United States

  • UNC Hospitals

    Chapel Hill, North Carolina, 27514, United States

  • UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu

    Botucatu, 18618-687, Brazil

  • Uludag Universitesi Tıp Fakultesi Hastanesi

    Bursa, 16059, Turkey (Türkiye)

  • Union Hospital Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, 430022, China

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    Dresden, 01307, Germany

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • Universitatsklinikum Schleswig Holstein Kiel

    Kiel, 24105, Germany

  • University Malaya Medical Centre

    Kuala Lumpur, 59100, Malaysia

  • Vasutegeszsegugyi Nonprofit Kozhasznu Kft

    Debrecen, 4025, Hungary

  • Vitaz

    Sint-Niklaas, 9100, Belgium

  • Washington Gastroenterology, PLLC

    Bellevue, Washington, 98004, United States

  • Washington Gastroenterology, PLLC

    Tacoma, Washington, 98405, United States

  • Whiston Hospital

    Prescot, L35 5DR, United Kingdom

  • Wollongong Private Hospital

    Wollongong, 2500, Australia

  • Wuxi People s Hospital

    Wuxi, 214023, China

  • Yeungnam University Hospital

    Daegu, 42415, South Korea

  • Yokohama City University Medical Center

    Yokohama, 232 0024, Japan

Conditions

Explore the condition pages connected to this study.