New dietary substitute shows promise for rare metabolic disorder
NCT ID NCT04761588
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a special powdered food called TYR Sphere in 14 people with tyrosinemia or alkaptonuria. The goal was to see if patients would stick with it, tolerate it well, and keep their metabolic levels in check. Participants used the product for 4 weeks, and researchers tracked their intake, any stomach issues, and blood levels of key amino acids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TYR Sphere (a special powdered food substitute low in phenylalanine and tyrosine)
- What this could lead to
- If successful, TYR Sphere could offer a more acceptable dietary option for managing tyrosinemia and alkaptonuria, helping patients stick to their diet and maintain metabolic control.
- What could go wrong
- This is a very small study (14 participants) with no control group, so results may not apply to everyone. It only tested short-term use (4 weeks), so long-term benefits or risks are unknown.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hopital Necker-Enfants Malades
Paris, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.