Can a simple drug make top surgery safer? new trial investigates
NCT ID NCT05794321
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether giving tranexamic acid (TXA) through an IV during gender affirming mastectomy (top surgery) can reduce complications like hematoma (blood collection) and seroma (fluid collection). 150 adults undergoing top surgery at UCSF will be randomly assigned to receive TXA or not. Researchers will track bleeding, drain output, and recovery time to see if TXA improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tranexamic acid (TXA)
What this could lead to
If it works, this could reduce complications like bleeding and fluid buildup after gender affirming mastectomy, leading to faster recovery.
What could go wrong
This is a small, early phase 2 trial. TXA may not reduce complications and carries a small risk of blood clots. Results may not apply to all surgery centers.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UCSF Department of Plastic & Reconstructive Surgery
RECRUITINGSan Francisco, California, 94131, United States
Contact Email: •••••@•••••