New drug duo targets Hard-to-Treat cancers in major trial

NCT ID NCT04579380

Ongoing Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

Summary

This study is testing whether the drugs tucatinib and trastuzumab can help control advanced solid tumors that have specific changes in a protein called HER2. It is for adults with cancers like lung, cervical, or uterine cancer that have spread or cannot be removed by surgery, and who have already tried other treatments. The main goal is to see if the treatment shrinks tumors and for how long, while closely monitoring side effects.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

1 S Park St Medical Center

Madison, Wisconsin, 53715, United States
AZ Groeninge

Kortrijk, 8500, Belgium
AZ Sint-Maarten

Mechelen, 2800, Belgium
Aichi Cancer Center Hospital

Nagoya, Aichi-ken, 464-8681, Japan
Ascires Eresa Campanar

Valencia, 46015, Spain
Barnes-Jewish Hospital Investigational Drug Pharmacy (IDS)

St Louis, Missouri, 63110, United States
CHU de Liege

Liège, 4000, Belgium
Cetir Centre Medic

Barcelona, 08029, Spain
Charite Universitatsmedizin Berlin

Berlin, 12203, Germany
City of Hope Torrance

Torrance, California, 90505, United States
City of Hope at Huntington Beach

Huntington Beach, California, 92648, United States
City of Hope at Irvine Sand Canyon

Irvine, California, 92618, United States
City of Hope at Long Beach Elm

Long Beach, California, 90813, United States
City of Hope at Long Beach Worsham

Long Beach, California, 90808, United States
City of Hope at Newport Beach Lido

Newport Beach, California, 92663, United States
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Diagnostic Centre

London, Others, W1G 7AF, United Kingdom
Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative lstituto Europeo di Oncologia

Milan, Milan, 20141, Italy
Duke University Medical Center/Duke Cancer Center

Durham, North Carolina, 27710, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Grand Hopital de Charleroi

Charleroi, Hainaut, B- 6060, Belgium
Guy's Hospital

London, SE1 9RT, United Kingdom
HonorHealth

Phoenix, Arizona, 85016, United States
HonorHealth

Tempe, Arizona, 85284, United States
Hospital Clínico Universitario de Valencia. Fundación Investigación Clínico de Valencia.

Valencia, 46010, Spain
Hospital Vithas Valencia 9 de Octubre

Valencia, 46015, Spain
Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Institut Catala d'Oncologia Hospitalet

L'Hospitalet de Llobregat, Other, 8908, Spain
Jonathan Poon

London, SE1 9RT, United Kingdom
Kindai University Hospital

Osakasayama-shi, Osaka, 589-8511, Japan
Koman Family Outpatient Pavilion

La Jolla, California, 92037, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Metro Minnesota Community Oncology Research Consortium (MMCORC)

Saint Louis Park, Minnesota, 55426, United States
Minnesota Oncology Hematology, PA

Coon Rapids, Minnesota, 55433, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
NYU Langone Health - Long Island (Winthrop Hospital)

Mineola, New York, 11501, United States
NYU Langone Medical Center

New York, New York, 10016, United States
National Cancer Center Hospital

Cho-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan
Northwest Cancer Specialists, P.C.

Portland, Oregon, 97213, United States
Northwest Cancer Specialists, P.C.

Portland, Oregon, 97227, United States
Northwest Cancer Specialists, P.C.

Tigard, Oregon, 97223, United States
Northwest Cancer Specialists, P.C.

Vancouver, Washington, 98684, United States
OSU Wexner Medical Center, Arther G. James Cancer Hospital, and Solove Research Institute

Columbus, Ohio, 43210, United States
OSU Wexner Medical Center, CarePoint East

Columbus, Ohio, 43203, United States
OSU Wexner Medical Center, CarePoint Gahanna

Gahanna, Ohio, 43230, United States
OSU Wexner Medical Center, Gynecologic Oncology at Mill Run

Hilliard, Ohio, 43026, United States
OSU Wexner Medical Center, Investigational Drug Services(IP Ship to)

Columbus, Ohio, 43210, United States
OSU Wexner Medical Center, Martha Morehouse Medical Plaza

Columbus, Ohio, 43221, United States
OSU Wexner Medical Center, Ohio State University Hospital East

Columbus, Ohio, 43203, United States
OSU Wexner Medical Center, OutPatient Care Upper Arlington

Columbus, Ohio, 43221, United States
OSU Wexner Medical Center, Outpatient Care Lewis Center

Lewis Center, Ohio, 43035, United States
OSU Wexner Medical Center, Outpatient Care New Albany

Westerville, Ohio, 43081, United States
OSU Wexner Medical Center, Stephanie Spielman Comprehensive Breast Center

Columbus, Ohio, 43212, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists

Omaha, Nebraska, 68114, United States
Oncology Hematology West P.C. dba Nebraska Cancer Specialists

Omaha, Nebraska, 68130, United States
Osu Wexner Medical Center, The Ohio State University Hospital

Columbus, Ohio, 43210, United States
Perlmutter Cancer Center at NYU Langone GYN Oncology Associates

Mineola, New York, 11501, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States
Prisma Health Cancer Institute

Boiling Springs, South Carolina, 29316, United States
Prisma Health Cancer Institute

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute

Seneca, South Carolina, 29672, United States
Radiology

London, W1G 8PP, United Kingdom
Rocky Mountain Cancer Centers

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers

Boulder, Colorado, 80303, United States
Rocky Mountain Cancer Centers

Thornton, Colorado, 80260, United States
Samsung Medical Center

Seoul, 06351, South Korea
Sarah Cannon Research Institute UK

London, Budapest, W1G 6AD, United Kingdom
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, Other, 03722, South Korea
St. Marianna University School of Medicine Hospital

Kawasaki, Kanagawa, 216-8511, Japan
Tennessee Oncology, PLLC

Gallatin, Tennessee, 37066, United States
Tennessee Oncology, PLLC

Hendersonville, Tennessee, 37075, United States
Tennessee Oncology, PLLC

Nashville, Tennessee, 37203, United States
Tennessee Oncology, PLLC

Shelbyville, Tennessee, 37160, United States
Texas Oncology - Central South

Waco, Texas, 76712, United States
Texas oncology-West Texas

Abilene, Texas, 79606, United States
The Cancer Institute Hospital of JFCR

Tokyo, 135-8550, Japan
The Harley Street Clinic

London, W1G 8BJ, United Kingdom
The Royal Marsden NHS Foundation Trust

Sutton, Surrey, SM2 5PT, United Kingdom
The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom
The University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion)

La Jolla, California, 92037, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92037, United States
UC San Diego Moores Cancer Center- Investigational Drug Services

La Jolla, California, 92037, United States
UH Minoff Health Center at Chagrin Highlands

Orange, Ohio, 44122, United States
UPMC Hillman Cancer Center - Washington

Washington, Pennsylvania, 15301, United States
US Oncology Investigational Product Center (IPC)

Irving, Texas, 75063, United States
US Oncology Investigational Products Center (IPC)

Irving, Texas, 75063, United States
US Oncology lnvestigational Products Center (IPC)

Irving, Texas, 75063, United States
Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
University of Wisconsin Clinical Science Center

Madison, Wisconsin, 53792, United States
Virginia Cancer Specialists, PC

Alexandria, Virginia, 22304, United States
Virginia Cancer Specialists, PC

Arlington, Virginia, 22205, United States
Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
Virginia Cancer Specialists, PC

Gainesville, Virginia, 20155, United States
Washington University School of Medicine - Obstetrics & Gynecology

St Louis, Missouri, 63110, United States
Washington University School of Medicine - Obstetrics & Gynecology [Academic Offices)

St Louis, Missouri, 63108, United States
Washington University School of Medicine [Patient Clinics]

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

BILIARY TRACT NEOPLASMS CARCINOMA, NON-SMALL-CELL LUNG HER2 MUTATIONS BREAST NEOPLASMS UROLOGIC NEOPLASMS UTERINE CERVICAL NEOPLASMS UTERINE NEOPLASMS