New drug combo targets Hard-to-Treat cancers in early trial

NCT ID NCT04485013

Recruiting now Disease control Sponsor: Tizona Therapeutics, Inc Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 09, 2026 · Updated 30 times

Summary

This early-stage study tests a new drug called TTX-080, which blocks a protein that helps cancers hide from the immune system. It is given alone or with other cancer drugs to people with advanced solid tumors (like colorectal cancer) that have not responded to standard therapies. The goal is to find a safe dose and see if the drug can shrink tumors or slow their growth.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AdventHealth Research Institute
COMPLETED

Orlando, Florida, 32804, United States
American Oncology Partners, P.A. - The Center for Cancer & Blood Disorders
RECRUITING

Bethesda, Maryland, 20817, United States

Contact Phone: •••-•••-••••
Arizona Oncology Associates
COMPLETED

Tucson, Arizona, 85711, United States
Christiana Care Helen F. Graham Cancer Center
COMPLETED

Newark, Delaware, 19713, United States
Dana-Farber Cancer Institute
COMPLETED

Boston, Massachusetts, 02215, United States
Florida Cancer Specialists
RECRUITING

Daytona Beach, Florida, 32117, United States

Contact Phone: •••-•••-••••
Florida Cancer Specialists
COMPLETED

Fleming Island, Florida, 32003, United States
Hoag Memorial Hospital
COMPLETED

Newport Beach, California, 92663, United States
Icahn School of Medicine at Mount Sinai
COMPLETED

New York, New York, 10029, United States
Illinois Cancer Specialists
COMPLETED

Arlington Heights, Illinois, 60005, United States
Indiana University
COMPLETED

Indianapolis, Indiana, 46202, United States
John Hopkins Kimmer Cancer Center
COMPLETED

Washington D.C., District of Columbia, 20016, United States
Maryland Oncology Hematology
RECRUITING

Silver Spring, Maryland, 20904, United States

Contact Phone: •••-•••-••••
Medical University of South Carolina
COMPLETED

Charleston, South Carolina, 29425, United States
NEXT Oncology
COMPLETED

San Antonio, Texas, 78229, United States
NEXT Oncology Virginia
RECRUITING

Fairfax, Virginia, 22031, United States

Contact Phone: •••-•••-••••
Nebraska Cancer Center Oncology Hematology West P.C.
RECRUITING

Omaha, Nebraska, 68130, United States

Contact Phone: •••-•••-••••
Northwest Cancer Specialists
COMPLETED

Vancouver, Washington, 98684, United States
Northwest Medical Specialties
COMPLETED

Tacoma, Washington, 98405, United States
Norton Cancer Institute
COMPLETED

Louisville, Kentucky, 40241, United States
Ocala Oncology Center
RECRUITING

Ocala, Florida, 34474, United States

Contact Phone: •••-•••-••••
Regions Hospital Cancer Care Center
RECRUITING

Saint Paul, Minnesota, 55101, United States

Contact Phone: •••-•••-••••
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States

Contact Phone: •••-•••-••••
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States

Contact Phone: •••-•••-••••
START Dallas
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Phone: •••-•••-••••
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States

Contact Phone: •••-•••-••••
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-••••
Stony Brook University
COMPLETED

Stony Brook, New York, 11794, United States
Texas Oncology - Dallas
RECRUITING

Dallas, Texas, 75246, United States

Contact Phone: •••-•••-••••
Texas Oncology - Paris
RECRUITING

Paris, Texas, 75460, United States

Contact Phone: •••-•••-••••
The University of Texas MD Anderson Cancer Center
COMPLETED

Houston, Texas, 77030, United States
The University of Toledo
COMPLETED

Toledo, Ohio, 43606, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45267, United States

Contact Phone: •••-•••-••••
University of Illinois
COMPLETED

Chicago, Illinois, 60612, United States
University of Oklahoma
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

Contact Phone: •••-•••-••••
University of Pittsburgh Medical Center
COMPLETED

Pittsburgh, Pennsylvania, 15232, United States
University of Southern California
COMPLETED

Los Angeles, California, 90033, United States
Vanderbilt - Ingram Cancer Center
COMPLETED

Nashville, Tennessee, 37232, United States
Washington University in St Louis
COMPLETED

St Louis, Missouri, 63110, United States
Yale Cancer Center
COMPLETED

New Haven, Connecticut, 06511, United States
Zangmeister Cancer Center
COMPLETED

Columbus, Ohio, 43219, United States

Conditions

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CANCER