Alzheimer's drug TRx0237 put to the test in large trial

NCT ID NCT03446001

Completed Disease control Sponsor: TauRx Therapeutics Ltd Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a drug called TRx0237 can help people with Alzheimer's disease. About 600 participants took either a low dose, a higher dose, or a placebo for 12 months, followed by a year where everyone could get the drug. The goal was to see if the drug slows memory loss and helps with daily activities. The trial is complete, and results will show if TRx0237 is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TRx0237 (a drug taken orally as tablets)
What this could lead to: If successful, this could lead to a treatment that slows or modifies the course of Alzheimer's disease, potentially helping patients maintain cognitive function and daily living skills longer.
What could go wrong: This is a Phase 3 trial, but previous similar drugs have failed. The results may show no benefit over placebo, and side effects could occur. The study is completed, so results are pending analysis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

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Locations

ATP Clinical Research, Inc.

Costa Mesa, California, 92626, United States
Advance Medical Research Center

Miami, Florida, 33135, United States
Advanced Memory Research of NJ PC

Toms River, New Jersey, 08755, United States
Albany Medical College

Albany, New York, 12208, United States
Allied Biomedical Research Institute

Miami, Florida, 33155, United States
Alpha Recherche Clinique

Québec, G3K 2P8, Canada
Alzheimer's Memory Center

Charlotte, North Carolina, 28270, United States
Alzheimer's Research and Treatment Center

Wellington, Florida, 33414, United States
Arizona Research Center

Phoenix, Arizona, 85053, United States
Atria Clinical Research

Little Rock, Arkansas, 72209, United States
Azienda Ospedaliera San Gerardo - Clinica Neurologica

Monza, 20900, Italy
Azienda Ospedaliera Sant'Andrea

Roma, 00189, Italy
Bioclinica Research

Orlando, Florida, 32806, United States
Biomed Research Institute, Inc

Miami, Florida, 33126, United States
CBRI - Roper Hospital

Charleston, South Carolina, 29414, United States
CCM Clinical Research Group

Miami, Florida, 33133, United States
CHU Bordeaux - Pellegrin

Bordeaux, 33076, France
CHU de Limoges

Limoges, 87042, France
CHU de Rennes

Rennes, 35009, France
CRC Gerontopole Cite de la Sante, Hôpital La Grave

Toulouse, 31059, France
California Neuroscience Medical Group

Sherman Oaks, California, 91403, United States
Centro de salud de San Juan, Unidad de Investigación Neurociencias

Salamanca, 37005, Spain
Centrum Medyczne NEUROMED

Bydgoszcz, 85-163, Poland
Centrum Medyczne NeuroProtect

Warsaw, 01-684, Poland
Clinica Neurologica Santa Maria della Misericordia

Udine, 33100, Italy
Clinique Mémoire de l'Outaouais

Gatineau, Quebec, J8T 8J1, Canada
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Coastal Neurology

Port Royal, South Carolina, 29935, United States
Emerald Coast Center for Neurological Disorders

Pensacola, Florida, 32504, United States
Euromedis Sp. z o.o.

Szczecin, 70-111, Poland
Excell Research, Inc.

Oceanside, California, 92056, United States
Finlay Medical Research

Greenacres City, Florida, 33467, United States
Finlay Medical Research

Miami, Florida, 33126, United States
Florida International Research Center

Miami, Florida, 33173, United States
Foundation Institute G.Giglio

Cefalù, 90015, Italy
Fullerton Neurology and Headache Center

Fullerton, California, 92835, United States
Future Care Solution, LLC

Miami, Florida, 33165, United States
Georgia Neurology and Sleep Medicine Associates

Suwanee, Georgia, 30024, United States
Glasgow Memory Clinic Ltd

Glasgow, G20 0XA, United Kingdom
Guidechauliac Hospital

Montpellier, 34295, France
HB Clinical Trials Inc.

Fountain Valley, California, 92708, United States
Health Care Family Rehab and Research

Miami, Florida, 33015, United States
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Hopital des Charpennes

Villeurbanne, 69100, France
Hospital General de Catalunya

Barcelona, 08195, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Doctor Peset

Valencia, 46017, Spain
Hospital Universitario Mutua Terrassa

Terrassa, 08222, Spain
Hospital Universitario QuironSalud Madrid

Madrid, 28223, Spain
Hospital Virgen de la Macarena

Seville, 41009, Spain
Hospitales de Madrid

Madrid, 28015, Spain
Hôpital Laënnec - CHU de Nantes

Nantes, 44093, France
Hôpital Neurologique Pierre Wertheimer

Bron, 69677, France
IMIC Inc

Palmetto Bay, Florida, 33157, United States
IPS Research Company

Oklahoma City, Oklahoma, 73106, United States
IRCCS Centro S. Giovanni di Dio Fatebenefratelli

Brescia, 25125, Italy
IRCCS Fondazione Santa Lucia

Rome, 00179, Italy
Imaging Endpoints Research

Scottsdale, Arizona, 85258, United States
Indago Research & Health Center, Inc.

Hialeah, Florida, 33012, United States
Indywidualna Praktyka Lekarska

Lublin, 20-582, Poland
Istituto Neurologico Casimiro Mondino, IRCCS

Pavia, 27100, Italy
Josephson Wallack Munshower Neurology P.C.

Indianapolis, Indiana, 46256, United States
Kingfisher Cooperative, LLC

Spokane, Washington, 99202, United States
L&C Professional Medical Research Institute

Miami, Florida, 33144, United States
MD Clinical

Hallandale, Florida, 33009, United States
Memory Clinic (Ottawa)

Ottawa, Ontario, K1Z 1G3, Canada
Merrit Island Medical Research

Merritt Island, Florida, 32952, United States
Miami Dade Medical Research Institute, LLC

Miami, Florida, 33176, United States
NZOZ Neuro-Kard

Poznan, 61-853, Poland
NZOZ Wielospecjalistyczna Poradnia Lekarska Synapsis

Katowice, 40-123, Poland
Neural Net Research

Portland, Oregon, 97225, United States
Neuro-Behavioral Clinical Research, Inc.

North Canton, Ohio, 44321, United States
NeuroStudies.net, LLC

Decatur, Georgia, 30033, United States
Neurology Diagnostics Inc.

Dayton, Ohio, 45459, United States
Neuroscience Research Center, LLC

Canton, Ohio, 44718, United States
Okanagan Clinical Trials, Ltd.

Kelowna, British Columbia, V1Y 1Z9, Canada
Optimus Clinical Research

Miami, Florida, 33125, United States
Ospedale San Giovanni Calibita Fatebenefratelli

Roma, 00186, Italy
Podlaskie Centrum Psychogeriatrii

Bialystok, 15-756, Poland
Progressive Medical Research

Port Orange, Florida, 32127, United States
Re:Cognition Health

Fairfax, Virginia, 22031, United States
Re:Cognition Health

Birmingham, B16 8LT, United Kingdom
Re:Cognition Health

Guildford, GU2 7YD, United Kingdom
Re:Cognition Health

Plymouth, PL6 8BT, United Kingdom
Re:Cognition Health - Central London

London, W1G 9JF, United Kingdom
Richmond Behavioral Associates

Staten Island, New York, 10312, United States
Senior Clinical Trials, Inc.

Laguna Hills, California, 92653, United States
Sensible Healthcare

Ocoee, Florida, 34761, United States
Sharp Mesa Vista Hospital

San Diego, California, 92123, United States
Stedman Clinical Trials

Tampa, Florida, 33613, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
The Lindner Research Center

Cincinnati, Ohio, 45219, United States
The Roskamp Institute, Inc.

Sarasota, Florida, 34243, United States
Timone Adults Hospital

Marseille, 13385, France
Tulsa Clinical Research LLC

Tulsa, Oklahoma, 74136, United States
UBMD Neurology

Buffalo, New York, 14203, United States
Universal Research Group, LLC

Tacoma, Washington, 98405, United States
University of Perugia, Ospedale S.M. della Misericordia

Perugia, 06156, Italy
Valley Medical Research

Centerville, Ohio, 45459, United States
Visionary Investigators Network

Aventura, Florida, 33180, United States
Visionary Investigators Network

Miami, Florida, 33176, United States
Vitae Research Center, LLC

Miami, Florida, 33135, United States
Xenoscience

Phoenix, Arizona, 85004, United States

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