Triple threat: new drug cocktail targets Hard-to-Treat bladder cancer
NCT ID NCT05335941
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 24 times
Summary
This phase 2 trial tests a combination of three drugs—pemetrexed, etrumadenant, and zimberelimab—in 10 people with advanced bladder cancer that has a specific genetic change (MTAP deficiency) and has already been treated with immunotherapy. The goal is to see if the triple therapy can shrink tumors and control the disease. Because it's a small, single-site study, the results will be very preliminary.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pemetrexed, etrumadenant, and zimberelimab (three drugs given together)
What this could lead to
If it works, this could point toward a new treatment option for people with a specific type of advanced bladder cancer that has stopped responding to immunotherapy.
What could go wrong
This is a very small, early-phase study with only 10 participants at one center. The combination may cause significant side effects, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.