A shield for bone marrow: can a drug stop Chemo's blood cell side effect?
NCT ID NCT07736001
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This trial tests whether a drug called trilaciclib can prevent myelosuppression — a drop in blood cell counts — caused by a type of chemotherapy known as topoisomerase I inhibitor antibody-drug conjugates (ADCs). About 96 cancer patients who are scheduled to receive these ADC drugs will get trilaciclib by infusion four hours before each chemo dose, for two treatment cycles. The main goal is to see how many patients avoid severe neutropenia (a dangerously low level of infection-fighting white blood cells).
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trilaciclib
- What this could lead to
- If effective, trilaciclib could become a standard preventive treatment to reduce severe neutropenia and other blood-related side effects from certain chemotherapy-like drugs.
- What could go wrong
- This is an early-phase, single-arm trial with only 96 participants, so results may not generalize. The drug itself may cause side effects, and its benefit over current care is unproven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
-
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
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