New drug targets rare gene changes in advanced cancers

NCT ID NCT03093116

Recruiting now Disease control Sponsor: Turning Point Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Apr 10, 2026 · Last updated May 15, 2026 · Updated 2 times

Summary

This study tests a new drug called repotrectinib in people with advanced solid tumors that have specific gene changes (ALK, ROS1, or NTRK). The goal is to see if the drug can shrink tumors and control the cancer. About 500 adults will take part, and the study has two phases: first to find the best dose, then to measure how well it works.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Locations

Anhui Provincial Hospital
RECRUITING

Hefei, 230001, China

Contact Phone: •••-•••-••••
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea

Contact Phone: •••-•••-••••
Baptist Memorial Hospital Baptist Cancer Center
RECRUITING

Memphis, Tennessee, 38120, United States

Contact
Beijing Cancer hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China

Contact Phone: •••-•••-••••
Centre Antoine-Lacassagne
RECRUITING

Nice, 06189, France

Contact Phone: •••-•••-••••
Centre Georges-Francois Leclerc
RECRUITING

Dijon, 21079, France

Contact Phone: •••-•••-••••
Centre Hospitalier Universitarie Grenoble Alpes (Chuga)
RECRUITING

Grenoble, 38043, France

Contact Phone: •••-•••-••••
Centro di Riferimento Oncologico
RECRUITING

Pordenone, 33081, Italy

Contact Phone: •••-•••-••••
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun-eup, Hwasun-gun, Jeollanam-do, 519-763, South Korea

Contact
Chris O'Brien LifeHouse
RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact Phone: •••-•••-••••
Daping Hospital, the Third Affiliated Hospital of Third Military Medical University /Cancer Center
RECRUITING

Daping, Chongqing Municipality, 00000, China

Contact Phone: •••-•••-••••
Ehime University Hospital
RECRUITING

Tōon, Ehime, 791-0295, Japan

Contact Phone: •••-•••-••••
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, MI, 20133, Italy

Contact Phone: •••-•••-••••
Guangdong Provincial People'S Hospital
RECRUITING

Guangzhou, Guangdong, 510120, China

Contact
Henan Cancer Hospital/The 1st pneumology department
RECRUITING

Zhengzhou, 00000, China

Contact Phone: •••-•••-••••
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 0608648, Japan

Contact Phone: •••-•••-••••
Hospital Universitario HM Sanchinarro CIOCC
RECRUITING

Madrid, 28050, Spain

Contact Phone: •••-•••-••••
Hospital Unversitario Val D'Hebrón
RECRUITING

Barcelona, 8035, Spain

Contact
Hunan Cancer Hospital-thoracic oncology II
RECRUITING

Changsha, Hunan, 410013, China

Contact Phone: •••-•••-••••
IRCCS Istituto Regina Elena Oncologia Medica 2
RECRUITING

Roma, 144, Italy

Contact Phone: •••-•••-••••
Institute Gustave Roussy
RECRUITING

Villejuif, 98405, France

Contact Phone: •••-•••-••••
Jilin Cancer Hospital/Medical Oncology Department
RECRUITING

Changchun, Jilin, 130012, China
Jilin Cancer Hospital/Medical Oncology Department
RECRUITING

Changchun, Jilin, 130012, China

Contact Phone: •••-•••-••••

Contact Phone: •••-•••-••••
Kanagawa cancer center
RECRUITING

Yokohama, Kanagawa, 2418515, Japan

Contact Phone: •••-•••-••••
Liaoning Cancer Hospital
RECRUITING

Shenyang, Liaoning, 110801, China

Contact
Local Institution - 1001
COMPLETED

Orange, California, 92868, United States
Local Institution - 1002
ACTIVE_NOT_RECRUITING

New York, New York, 10065, United States
Local Institution - 1003
COMPLETED

Aurora, Colorado, 80045, United States
Local Institution - 1004
COMPLETED

Boston, Massachusetts, 02214, United States
Local Institution - 2101
COMPLETED

Orange, California, 92868, United States
Local Institution - 2102
COMPLETED

New York, New York, 10065, United States
Local Institution - 2103
COMPLETED

Aurora, Colorado, 80045, United States
Local Institution - 2105
COMPLETED

Ann Arbor, Michigan, 48109, United States
Local Institution - 2106
COMPLETED

Washington D.C., District of Columbia, 20007, United States
Local Institution - 2107
COMPLETED

Seattle, Washington, 98109, United States
Local Institution - 2108
COMPLETED

Philadelphia, Pennsylvania, 19111-2497, United States
Local Institution - 2109
COMPLETED

Cleveland, Ohio, 44195, United States
Local Institution - 2110
COMPLETED

Washington D.C., District of Columbia, 20016, United States
Local Institution - 2111
COMPLETED

Detroit, Michigan, 48201, United States
Local Institution - 2112
COMPLETED

Canton, Ohio, 44718, United States
Local Institution - 2113
COMPLETED

Tampa, Florida, 33612, United States
Local Institution - 2114
COMPLETED

La Jolla, California, 92093, United States
Local Institution - 2116
NOT_YET_RECRUITING

New Orleans, Louisiana, 70121, United States

Contact
Local Institution - 2117
COMPLETED

New York, New York, 10016, United States
Local Institution - 2119
COMPLETED

Toledo, Ohio, 43614, United States
Local Institution - 2120
COMPLETED

Glendale, California, 91206, United States
Local Institution - 2121
COMPLETED

Long Beach, California, 90813, United States
Local Institution - 2122
COMPLETED

New Brunswick, New Jersey, 08901, United States
Local Institution - 2127
COMPLETED

Houston, Texas, 77030, United States
Local Institution - 2129
COMPLETED

Duarte, California, 91010, United States
Local Institution - 2131
COMPLETED

Boston, Massachusetts, 02215, United States
Local Institution - 2132
COMPLETED

Saint Paul, Minnesota, 55101, United States
Local Institution - 2133
COMPLETED

Baltimore, Maryland, 21210, United States
Local Institution - 2134
COMPLETED

Columbus, Georgia, 31904, United States
Local Institution - 2136
WITHDRAWN

La Jolla, California, 92037, United States
Local Institution - 2137
COMPLETED

Fairfax, Virginia, 22031, United States
Local Institution - 2140
COMPLETED

Detroit, Michigan, 48202-2608, United States
Local Institution - 2141
WITHDRAWN

Tacoma, Washington, 98405, United States
Local Institution - 2142
COMPLETED

Peoria, Illinois, 61615, United States
Local Institution - 2143
COMPLETED

Cincinnati, Ohio, 45220, United States
Local Institution - 2144
COMPLETED

Goldsboro, North Carolina, 27534, United States
Local Institution - 2145
COMPLETED

Appleton, Wisconsin, 54911, United States
Local Institution - 2146
COMPLETED

Kingwood, Texas, 77339, United States
Local Institution - 2147
COMPLETED

Bolivar, Missouri, 65613, United States
Local Institution - 2201
COMPLETED

Toronto, Ontario, M5G 2M9, Canada
Local Institution - 2202
COMPLETED

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 2203
COMPLETED

Ontario, L6R 37R, Canada
Local Institution - 2204
COMPLETED

Ottawa, K1H 8L6, Canada
Local Institution - 2205
WITHDRAWN

Vancouver, British Columbia, V5Z 4E7, Canada
Local Institution - 3001
COMPLETED

Seoul, 03080, South Korea
Local Institution - 3002
COMPLETED

Seoul, Seodaemun-gu, 03722, South Korea
Local Institution - 3002
WITHDRAWN

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Local Institution - 3003
COMPLETED

Seoul, Gangnam-gu, 06351, South Korea
Local Institution - 3301
COMPLETED

East Melbourne, 3002, Australia
Local Institution - 4102
COMPLETED

Barcelona, 08028, Spain
Local Institution - 4103
COMPLETED

Madrid, 28041, Spain
Local Institution - 4106
COMPLETED

Madrid, 28033, Spain
Local Institution - 4107
COMPLETED

Valencia, 46009, Spain
Local Institution - 4108
COMPLETED

Pamplona, 31008, Spain
Local Institution - 4201
COMPLETED

Marseille, Bouches-du-Rhône, 13005, France
Local Institution - 4203
COMPLETED

Saint-Mandé, 94163, France
Local Institution - 4207
COMPLETED

Brest, 29200, France
Local Institution - 4208
COMPLETED

Poitiers, 86000, France
Local Institution - 4302
COMPLETED

Terni, 05100, Italy
Local Institution - 4304
NOT_YET_RECRUITING

Ravenna, 48121, Italy

Contact
Local Institution - 4305
COMPLETED

Reggio Emilia, 42123, Italy
Local Institution - 4306
COMPLETED

Milan, 20122, Italy
Local Institution - 4307
WITHDRAWN

Palermo, 90146, Italy
Local Institution - 4401
COMPLETED

London, SW3 6JJ, United Kingdom
Local Institution - 4402
COMPLETED

London, W12 OHS, United Kingdom
Local Institution - 4403
COMPLETED

Manchester, M20 4BX, United Kingdom
Local Institution - 4404
COMPLETED

London, W1G 6AD, United Kingdom
Local Institution - 4405
COMPLETED

Sutton, SM2 5PT, United Kingdom
Local Institution - 4501
COMPLETED

Groningen, 9713 GZ, Netherlands
Local Institution - 4502
COMPLETED

Amsterdam, 1066 CX, Netherlands
Local Institution - 4602
COMPLETED

Warsaw, 02-781, Poland
Local Institution - 4603
COMPLETED

Szczecin, 70-784, Poland
Local Institution - 4604
COMPLETED

Lublin, 20-609, Poland
Local Institution - 4605
COMPLETED

Poznan, 60-693, Poland
Local Institution - 4701
COMPLETED

Cologne, 50937, Germany
Local Institution - 4702
COMPLETED

Heidelberg, 69120, Germany
Local Institution - 4703
COMPLETED

Dresden, 01307, Germany
Local Institution - 4704
COMPLETED

Berlin, 13125, Germany
Local Institution - 4801
COMPLETED

Leuven, 3000, Belgium
Local Institution - 4802
COMPLETED

Antwerp, 2650, Belgium
Local Institution - 4901
COMPLETED

Copenhagen, 2100, Denmark
Local Institution - 5101
COMPLETED

Budapest, 1083, Hungary
Local Institution - 5103
COMPLETED

Budapest, 1121, Hungary
Local Institution - 6103
COMPLETED

Adelaide, South Australia, 5042, Australia
Local Institution - 6201
ACTIVE_NOT_RECRUITING

Taiepi, 100, Taiwan
Local Institution - 6202
COMPLETED

Taipei, 10449, Taiwan
Local Institution - 6203
ACTIVE_NOT_RECRUITING

Tainan, 704, Taiwan
Local Institution - 6304
COMPLETED

Seoul, 06591, South Korea
Local Institution - 6306
COMPLETED

Cheongju-si, 28644, South Korea
Local Institution - 6307
COMPLETED

Seoul, 05030, South Korea
Local Institution - 6501
ACTIVE_NOT_RECRUITING

Hong Kong, Hong Kong
Local Institution - 6502
ACTIVE_NOT_RECRUITING

Hong Kong, 0, Hong Kong
Local Institution - 6503
ACTIVE_NOT_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Local Institution - 6504
ACTIVE_NOT_RECRUITING

Shatin, HONG KONG, 999077, China
Local Institution - 6505
ACTIVE_NOT_RECRUITING

Shenzhen, Guangdong, 518053, China
Local Institution - 6702
COMPLETED

Beijing, Beijing Municipality, 100021, China
Local Institution - 6705
COMPLETED

Changsha, Hunan, 410011, China
Local Institution - 6719
COMPLETED

Fuzhou, Fujian, 000000, China
Local Institution - 6725
COMPLETED

Hangzhou, Zhejiang, 310016, China
Local Institution - 6733
COMPLETED

Guangzhou, Guangdong, 510120, China
Local Institution - 6748
COMPLETED

Nanjing, Jiangsu, 210008, China
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
Massachusetts General Hospital,
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Phone: •••-•••-••••
Memorial Healthcare System
RECRUITING

Hollywood, Florida, 33021, United States

Contact Phone: •••-•••-••••
Nagoya University Hospital
RECRUITING

Nagoya, 466-8560, Japan

Contact Phone: •••-•••-••••
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277-8577, Japan

Contact Phone: •••-•••-••••
National Cancer Center Hospital.
RECRUITING

Chuo-ku, Tokyo, 1040045, Japan

Contact Phone: •••-•••-••••
National Cancer Center Singapore
RECRUITING

Singapore, 169610, Singapore

Contact Phone: •••-•••-••••
National University Hospital
RECRUITING

Singapore, 119074, Singapore

Contact Phone: •••-•••-••••
Osaka City General Hospital
RECRUITING

Osaka, Osaka, 5340021, Japan

Contact Phone: •••-•••-••••
Osaka International Cancer institute
RECRUITING

Osaka, 5418567, Japan

Contact Phone: •••-•••-••••
Ośrodek Badań Klinicznych Wczesnych Faz, Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland

Contact Phone: •••-•••-••••
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, Victoria, 3000, Australia

Contact Phone: •••-•••-••••
START Madrid-FJD
RECRUITING

Madrid, 28040, Spain

Contact Phone: •••-•••-••••
Samsung Medical Center
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

Contact Phone: •••-•••-••••
Seoul National University Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

Contact Phone: •••-•••-••••
Shanghai Chest Hospital
RECRUITING

Shanghai, 200030, China
Shanghai Chest Hospital
RECRUITING

Shanghai, 200030, China

Contact

Contact Phone: •••-•••-••••
Shanxi Bethune Hospital
RECRUITING

Taiyuan, Shanxi, 030032, China

Contact Phone: •••-•••-••••
Sichuan Cancer Hospital/Medical Oncology Department
RECRUITING

Chengdu, Sichuan, 00000, China

Contact Phone: •••-•••-••••
St Joseph Heritage Healthcare
RECRUITING

Santa Rosa, California, 95403, United States

Contact
Tangdu Hospital
RECRUITING

Xi'an, Shan3xi, 710038, China

Contact
The Affiliated Tumor Hospital of Harbin Medical University
RECRUITING

Harbin, Heilongjiang, 150081, China

Contact Phone: •••-•••-••••
The First Affiliated Hospital - Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310003, China

Contact Phone: •••-•••-••••
The First Affiliated hospital of Xiamen University-oncology
RECRUITING

Xiamen, Fujian, 361003, China

Contact Phone: •••-•••-••••
The First Hospital Affiliated To AMU - Southwest Hospital
RECRUITING

Chongqing, Sichuan, 400030, China

Contact Phone: •••-•••-••••
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States

Contact Phone: •••-•••-••••
The Third Xiangya Hospital of Central South University/Department of Respiratory and Critical Care Medicine
RECRUITING

Changsha, 00000, China

Contact
The first hospital of Jilin university-Oncology Department
RECRUITING

Changchun, Jilin, 130021, China

Contact Phone: •••-•••-••••
Tottori University Hospital
RECRUITING

Yonago, Tottori, 683-8504, Japan

Contact
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

Contact Phone: •••-•••-••••
Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology/Cancer Center Department
RECRUITING

Wuhan, Hubei, 430022, China

Contact Phone: •••-•••-••••
University Cancer and Blood Center
RECRUITING

Athens, Georgia, 30607, United States

Contact Phone: •••-•••-••••
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

Contact Phone: •••-•••-••••
Washington University Infusion Center Pharmacy
RECRUITING

St Louis, Missouri, 63110, United States

Contact Phone: •••-•••-••••
Weifang People's Hospital/Medical Oncology Department
RECRUITING

Weifang, 00000, China

Contact
West China Hospital Sichuan University/Lung cancer center
RECRUITING

Chengdu, 00000, China

Contact Phone: •••-•••-••••
XuZhou Central Hospital/Oncology Department
RECRUITING

Xuzhou, Jiangsu, 00000, China

Contact
Yonsei University Health System, Severance Hospital
RECRUITING

Seoul, 03722, South Korea

Contact Phone: •••-•••-••••
Zhejiang Cancer Hospital-Oncology
RECRUITING

Hangzhou, Zhejiang, 310022, China

Contact

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED SOLID TUMORS METASTATIC SOLID TUMORS