New antibody injection could shrink nasal polyps and ease breathing

NCT ID NCT07107256

Recruiting now Disease control Sponsor: Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests an injectable drug called TQC2731 in 246 adults with chronic sinusitis and nasal polyps. The drug targets a protein involved in inflammation. Researchers will measure changes in polyp size and nasal congestion over 24 weeks compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TQC2731 injection (a lab-made antibody that blocks inflammation)
What this could lead to: If it works, this could offer a new treatment option to shrink nasal polyps and ease congestion for people with chronic sinusitis.
What could go wrong: This is a phase 3 trial, but results may not show clear benefit over placebo. Side effects from blocking the immune system are possible, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS (CRSWNP)

Contacts and locations

Locations

Affiliated Hospital of Inner Mongolia Medical University
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 10000, China
Affiliated Hospital of Yangzhou Univrtsity
NOT_YET_RECRUITING

Yangzhou, Jiangsu, 225000, China
Affiliated Zhongshan Hospital Of Dalian University
NOT_YET_RECRUITING

Dalian, Jilin, 116001, China
Affilited hangzhou first people's hospital, school of medicine, westlakeuniversity
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310006, China
Beijing youan hospital，capital medical university
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100069, China
Cangzhou Central Hospital
NOT_YET_RECRUITING

Cangzhou, Hebei, 61012, China
Chengdu Second People's Hospital
NOT_YET_RECRUITING

Chengdu, Sichuan, 610017, China
Chifeng Municipal Hospital
NOT_YET_RECRUITING

Chifeng, Inner Mongolia, 24000, China
China Medical University Affiliated Shengjing Hospital
NOT_YET_RECRUITING

Shenyang, Liaoning, 110004, China
China-Japan Union Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Daqing People's Hospital
NOT_YET_RECRUITING

Daqing, Heilongjiang, 163316, China
Eye&ENT Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200031, China
Fengcheng People's Hospital
NOT_YET_RECRUITING

Fengcheng, Jiangxi, 331100, China
First Hospital of Shanxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030045, China
Ganzhou People's Hospital
NOT_YET_RECRUITING

Ganzhou, Jiangxi, 341000, China
Hebei Medical University Third Hospital
NOT_YET_RECRUITING

Shijiazhuang, Hebei, 065799, China
Hebei Petro China Central Hospital
NOT_YET_RECRUITING

Langfang, Hebei, 650000, China
Henan Provincial People'S Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
Jiangnan University Medical Center
NOT_YET_RECRUITING

Wuxi, Jiangsu, 214000, China
Jingzhou Central Hospital
NOT_YET_RECRUITING

Jingzhou, Hubei, 434000, China
Linfen Central Hospital
NOT_YET_RECRUITING

Lifen, Shanxi, 041000, China
Liuzhou People's Hospital
NOT_YET_RECRUITING

Liuzhou, Guangxi, 545200, China
Ningbo No.2 Hospital
NOT_YET_RECRUITING

Ningbo, Zhejiang, 315010, China
Peking University People'S Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100044, China
People's Hospital of Hunan Province
NOT_YET_RECRUITING

Changsha, Hunan, 410002, China
Qingdao Municipal Hospital
NOT_YET_RECRUITING

Qingdao, Shandong, 266000, China
Renji Hospital,Shanghai Jiao Tong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200127, China
Shandong Second Province General Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250021, China
ShangRao People's Hospital
NOT_YET_RECRUITING

Shangrao, Jiangxi, 334000, China
Shanghai Sixth People's Hospital
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200233, China
Shenzhen Second People'S Hospital
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518035, China
Taizhou First People's Hospital
NOT_YET_RECRUITING

Taizhou, Zhejiang, 318020, China
The 940th Hospital of Joint Logistics Support force of Chinese People 's Liberation Army
NOT_YET_RECRUITING

Lanzhou, Gansu, 730050, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Hebei North University
NOT_YET_RECRUITING

Zhangjiakou, Hebei, 75000, China
The First Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITING

Kunming, Yunnan, 650032, China
The First Affiliated Hospital of NanChang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Ningbo University
NOT_YET_RECRUITING

Ningbo, Zhejiang, 315000, China
The First Affiliated Hospital of Xi'an Jiao Tong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Xiamen University
NOT_YET_RECRUITING

Xiamen, Fujian, 361000, China
The First Affiliated Hospital of Xinjiang Medical University
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830000, China
The First People'S Hospital of Lianyungang
NOT_YET_RECRUITING

Lianyungang, Jiangsu, 222000, China
The First People's Hospital of Changde City
NOT_YET_RECRUITING

Changde, Hunan, 415000, China
The Second Affiliated Hospital Of Xi'an Jiaotong University
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710004, China
The Second Affiliated Hospital of Anhui Medical University
NOT_YET_RECRUITING

Hefei, Anhui, 230601, China
The Second Affiliated Hospital of Guangzhou Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510405, China
The Third Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410013, China
The first hospital of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
Tianjin First Central Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300190, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430022, China
West China Hospital of Si chuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610000, China
Xuzhou Medical University Affiliated Hospital
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221000, China
Yan'an University Xianyang Hospital
NOT_YET_RECRUITING

Xianyang, Shaanxi, 712000, China
Yantai Yuhuangding Hospital
NOT_YET_RECRUITING

Yantai, Shandong, 264000, China
Yuncheng Central Hospital，Shanxi Province
NOT_YET_RECRUITING

Yuncheng, Shanxi, 44099, China
Zhejiang Provincial People's Hospital
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310014, China
Zhongda Hosiptal Southeast University
NOT_YET_RECRUITING

Fuyang, Anhui, 236600, China
Zhongda Hospital affiliated to Southeast University
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210009, China
Zhongshan Hospital, Fudan University
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Zibo Central Hospital
NOT_YET_RECRUITING

Zibo, Shandong, 255020, China

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