New pill shows promise for Hard-to-Treat transplant complication

NCT ID NCT04944043

First seen Jan 10, 2026 · Last updated Apr 25, 2026 · Updated 17 times

Summary

This study tests an experimental tablet called TQ05105 in 45 adults with moderate to severe chronic graft-versus-host disease (cGVHD) that hasn't improved with steroids. The goal is to find the best dose and see if it can control the disease and ease symptoms. Participants take the tablet by mouth, and doctors monitor their response over time.

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Contacts and locations

Locations

  • Guangzhou First People's Hospital

    Guangzhou, Guangdong, 511457, China

  • Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

    Tianjin, Tianjin Municipality, 300020, China

  • Nanfang Hospital of Southern Medical University

    Guangzhou, Guangdong, 510515, China

  • The First Affiliated Hospital of Guangxi Medical University

    Nanning, Guangxi, 530021, China

  • The First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215006, China

  • The First Affiliated Hospital of USTC (Anhui Provincial Hospital)

    Hefei, Anhui, 230001, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hanzhou, Zhejiang, 310000, China

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050000, China

  • Tongji Hospital Tongji Medical College of HUST

    Wuhan, Hubei, 430030, China

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • Zhujiang Hospital of Southern Medical University

    Guangzhou, Guangdong, 510280, China

Conditions

Explore the condition pages connected to this study.