Clot-Busting drug may help clear brain bleeds during surgery
NCT ID NCT05491356
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving a clot-busting drug called tPA directly into a chronic subdural hematoma (a slow brain bleed) helps drain it better during surgery. Forty adults who needed a twist-drill drainage procedure took part. The main goal was to see if the approach is feasible and safe, not yet to prove it works better than standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tissue plasminogen activator (tPA)
What this could lead to
If it works, this could lead to a better way to clear blood clots from the brain, possibly reducing the need for repeat surgeries.
What could go wrong
This is a small pilot study with only 40 people, so results may not apply widely. tPA also carries a risk of bleeding, especially in patients on blood thinners.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hamilton General Hospital
Hamilton, Ontario, L8L 2X2, Canada