Clot-Busting drug may help clear brain bleeds during surgery
NCT ID NCT05491356
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving a clot-busting drug called tPA directly into a chronic subdural hematoma (a slow brain bleed) helps drain it better during surgery. Forty adults who needed a twist-drill drainage procedure took part. The main goal was to see if the approach is feasible and safe, not yet to prove it works better than standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tissue plasminogen activator (tPA)
- What this could lead to
- If it works, this could lead to a better way to clear blood clots from the brain, possibly reducing the need for repeat surgeries.
- What could go wrong
- This is a small pilot study with only 40 people, so results may not apply widely. tPA also carries a risk of bleeding, especially in patients on blood thinners.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hamilton General Hospital
Hamilton, Ontario, L8L 2X2, Canada
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Other studies related to the condition(s) this trial covers.