New drug aims to stop viral lung infections from turning deadly

NCT ID NCT05624450

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing an experimental drug called tozorakimab for people who are hospitalized with a serious viral lung infection and need extra oxygen. The main goal is to see if adding this drug to standard hospital care can help prevent patients from dying or needing a breathing machine. Researchers will compare the drug to a placebo in about 2,870 adults.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Research Site
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Mobile, Alabama, 36608, United States
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Phoenix, Arizona, 85008, United States
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Phoenix, Arizona, 85013, United States
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Tucson, Arizona, 85719, United States
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Chula Vista, California, 91911, United States
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Fresno, California, 93701, United States
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La Mesa, California, 91942, United States
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Los Angeles, California, 90027, United States
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Newport Beach, California, 92663, United States
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Torrance, California, 90505, United States
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Colorado Springs, Colorado, 80909, United States
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Denver, Colorado, 80206, United States
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Washington D.C., District of Columbia, 20037, United States
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Bradenton, Florida, 34209, United States
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Bradenton, Florida, 34209, United States
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Gainesville, Florida, 32611, United States
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Jacksonville, Florida, 32224, United States
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Lakeland, Florida, 33805, United States
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WITHDRAWN

Miami, Florida, 33144, United States
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COMPLETED

South Pasadena, Florida, 33707, United States
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St. Petersburg, Florida, 33709, United States
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Tampa, Florida, 33617, United States
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Atlanta, Georgia, 30322, United States
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Boise, Idaho, 83702, United States
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COMPLETED

Chicago, Illinois, 60612, United States
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Elmhurst, Illinois, 60126, United States
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Evanston, Illinois, 60201, United States
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Fort Wayne, Indiana, 46804, United States
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Iowa City, Iowa, 52242, United States
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Kansas City, Kansas, 66160, United States
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Louisville, Kentucky, 40202, United States
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Baton Rouge, Louisiana, 70808, United States
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New Orleans, Louisiana, 70121, United States
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Shreveport, Louisiana, 71103, United States
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Annapolis, Maryland, 21401, United States
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Silver Spring, Maryland, 20910, United States
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COMPLETED

Springfield, Massachusetts, 01199, United States
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Worcester, Massachusetts, 01655, United States
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Detroit, Michigan, 48202, United States
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Royal Oak, Michigan, 48073, United States
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Saint Paul, Minnesota, 55101, United States
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Columbia, Missouri, 65212, United States
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Kansas City, Missouri, 64108, United States
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St Louis, Missouri, 63110, United States
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Brooklyn, New York, 11203, United States
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New York, New York, 10016, United States
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New York, New York, 10039, United States
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Potsdam, New York, 13676, United States
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Chapel Hill, North Carolina, 27514, United States
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Greenville, North Carolina, 27834, United States
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Winston-Salem, North Carolina, 27157, United States
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Columbus, Ohio, 43210, United States
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Oklahoma City, Oklahoma, 73104, United States
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Corvallis, Oregon, 97330, United States
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Portland, Oregon, 97239, United States
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Philadelphia, Pennsylvania, 19107, United States
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COMPLETED

Providence, Rhode Island, 02903, United States
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Greenville, South Carolina, 29605, United States
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Sioux Falls, South Dakota, 57105, United States
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Dallas, Texas, 75203, United States
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Dallas, Texas, 75204, United States
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El Paso, Texas, 79905, United States
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COMPLETED

Houston, Texas, 77030, United States
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WITHDRAWN

Houston, Texas, 77090, United States
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Salt Lake City, Utah, 84107, United States
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Charlottesville, Virginia, 22908, United States
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Green Bay, Wisconsin, 54311, United States
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Milwaukee, Wisconsin, 53295, United States
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COMPLETED

Buenos Aires, C1046, Argentina
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COMPLETED

Buenos Aires, C1120AAF, Argentina
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Buenos Aires, C1180AAV, Argentina
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COMPLETED

CABA, C1221ADC, Argentina
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WITHDRAWN

CABA, C1425EOE, Argentina
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La Plata, B1900AVG, Argentina
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COMPLETED

Mar del Plata, B7600GWV, Argentina
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Munro, B1605FRE, Argentina
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COMPLETED

Rosario, S2000CVB, Argentina
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Adelaide, 5000, Australia
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Bedford Park, 5042, Australia
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COMPLETED

New Lambton Heights, 2305, Australia
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Port Macquarie, 2444, Australia
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South Brisbane, 4101, Australia
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Kortrijk, 8500, Belgium
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Ottignies, 1340, Belgium
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Roeselare, 8800, Belgium
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Yvoir, 5530, Belgium
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Belo Horizonte, 30150-221, Brazil
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Campinas, 13060-904, Brazil
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Caxias do Sul, 95070-560, Brazil
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Curitiba, 80215-901, Brazil
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Curitiba, 80730-150, Brazil
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SUSPENDED

Indaiatuba, 13331-501, Brazil
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Jaú, 17201-130, Brazil
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Natal, 59025-050, Brazil
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Niterói, 24020-096, Brazil
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Passo Fundo, 99010-260, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 9061-000, Brazil
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Recife, 50070-070, Brazil
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Ribeirão Preto, 14049-901, Brazil
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Rio de Janeiro, 21040-900, Brazil
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Salvador, 40170-130, Brazil
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São Caetano do Sul, 09521-160, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04004-030, Brazil
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São Paulo, 09323-900, Brazil
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Montana, 3400, Bulgaria
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SUSPENDED

Pernik, 2300, Bulgaria
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SUSPENDED

Pleven, 5800, Bulgaria
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SUSPENDED

Rousse, 7002, Bulgaria
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WITHDRAWN

Sofia, 1000, Bulgaria
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Sofia, 1154, Bulgaria
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Sofia, 1407, Bulgaria
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Sofia, 1431, Bulgaria
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SUSPENDED

Sofia, 1606, Bulgaria
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Varna, 9010, Bulgaria
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RECRUITING

Calgary, Alberta, T2N 1N4, Canada
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New Westminster, British Columbia, V3L 3W7, Canada
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Winnipeg, Manitoba, R2H 2A6, Canada
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Winnipeg, Manitoba, R3A 1R9, Canada
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Winnipeg, Manitoba, R3J 3M7, Canada
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Brampton, Ontario, L6R 3J9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Ottawa, Ontario, K1Y 4E9, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Lévis, Quebec, G6V 3Z1, Canada
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Montreal, Quebec, H1T 2M4, Canada
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Montreal, Quebec, H2W 1S6, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Québec, Quebec, G1V 4G5, Canada
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Saskatoon, Saskatchewan, S7N 0W8, Canada
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Beijing, 100015, China
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Beijing, 100029, China
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Beijing, 101199, China
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Beijing, China
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Changsha, 410004, China
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Changsha, 410015, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400010, China
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Fuyang, 236012, China
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Guangzhou, 510180, China
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Guangzhou, 510515, China
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Haikou, 570311, China
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Hangzhou, 310006, China
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Hangzhou, 310016, China
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Hefei, 230001, China
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Jining, 272006, China
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Nanchang, 330006, China
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Nantong, 226001, China
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Qingdao, 266011, China
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Shanghai, 200025, China
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Shanghai, 200032, China
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Shanghai, 200240, China
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Shanghai, 201199, China
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Shanghai, CN-200433, China
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Shenzhen, 518020, China
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Tianjin, 300050, China
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Weifang, 261041, China
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Wuhan, 430023, China
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Wuhan, 430030, China
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Yantai, 264000, China
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Yinchuan, 750004, China
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Yueyang, 414000, China
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Zhengzhou, 450000, China
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WITHDRAWN

Bogota DC, 111121, Colombia
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COMPLETED

Floridablanca, 681004, Colombia
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COMPLETED

Medellín, 050021, Colombia
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COMPLETED

Soledad, 083001, Colombia
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COMPLETED

Villavicencio, 500001, Colombia
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COMPLETED

Benešov, 256 01, Czechia
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COMPLETED

Brno, 625 00, Czechia
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WITHDRAWN

Hradec Králové, 500 05, Czechia
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RECRUITING

Kolín, 280 02, Czechia
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COMPLETED

Kyjov, 697 01, Czechia
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Mladá Boleslav, 293 01, Czechia
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Prague, 100 34, Czechia
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WITHDRAWN

Prague, 150 30, Czechia
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Prague, 18000, Czechia
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Aalborg, 9000, Denmark
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Aarhus N, 8200, Denmark
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Copenhagen, 2400, Denmark
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Copenhagen Ø, 2100, Denmark
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Herning, 7400, Denmark
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Hillerød, 3400, Denmark
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Hvidovre, 2650, Denmark
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Kolding, 6000, Denmark
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Odense C, 5000, Denmark
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Vejle, 7100, Denmark
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WITHDRAWN

Alexandria, 21131, Egypt
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Cairo, 11561, Egypt
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Cairo, 11566, Egypt
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New Cairo, 11566, Egypt
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Amiens, 80054, France
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Angers, 49033, France
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Brest, 29609, France
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Créteil, 94000, France
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Dijon, 21000, France
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La Tronche, 38700, France
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Le Coudray, 28630, France
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Montpellier, 34295, France
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Nantes, 44800, France
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Orléans, 45100, France
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Strasbourg, 67091, France
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Strasbourg, 67098, France
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Tours, 37000, France
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Augsburg, 86156, Germany
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Berlin, 10117, Germany
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Berlin, 12351, Germany
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Cologne, 51109, Germany
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Hamburg, 20246, Germany
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Hanover, 30625, Germany
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Kiel, 24105, Germany
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Leverkusen, 51375, Germany
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Marburg, 35043, Germany
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Regensburg, 93053, Germany
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Rosenheim, 83022, Germany
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Rostock, 18057, Germany
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Athens, 11527, Greece
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Athens, 12462, Greece
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Exohi Thessaloniki, 57010, Greece
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Heraklion, 71500, Greece
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Ioannina, 45500, Greece
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Thessaloniki, 57010, Greece
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Hong Kong, 999077, Hong Kong
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Shatin, 00000, Hong Kong
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RECRUITING

Balassagyarmat, 2660, Hungary
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Budapest, 1082, Hungary
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COMPLETED

Budapest, 1121, Hungary
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Debrecen, 4032, Hungary
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COMPLETED

Győr, 9024, Hungary
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WITHDRAWN

Kistarcsa, 2143, Hungary
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Nyíregyháza, 4400, Hungary
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Pécs, 7624, Hungary
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SUSPENDED

Ahmedabad, 380054, India
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SUSPENDED

Ahmedabad, 382415, India
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Belagavi, 590010, India
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Chennai, 600113, India
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Gurugram, 122001, India
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Gūrgaon, 122001, India
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Hyderabad, 500035, India
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NOT_YET_RECRUITING

Hyderabad, 500068, India
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NOT_YET_RECRUITING

Kanpur, 208002, India
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WITHDRAWN

Mumbai, 400008, India
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New Delhi, 110017, India
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New Delhi, 110029, India
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New Delhi, 110060, India
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SUSPENDED

Pune, 411043, India
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SUSPENDED

Thane, 401107, India
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NOT_YET_RECRUITING

Vijayawada, 520 008, India
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Afula, 18341, Israel
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Ashkelon, 7830604, Israel
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Beersheba, 8410101, Israel
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Haifa, 34362, Israel
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Holon, 58100, Israel
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Jerusalem, 91120, Israel
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TERMINATED

Petah Tikva, 4941492, Israel
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Ramat Gan, 52621, Israel
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Rehovot, 76100, Israel
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Arezzo, 52100, Italy
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Brescia, 25123, Italy
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Naples, 80131, Italy
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Roma, 00128, Italy
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Roma, 00149, Italy
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Rozzano, 20089, Italy
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Torino, 10149, Italy
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Chiba, 260-0852, Japan
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Fukuoka, 814-0180, Japan
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Gifu, 502-8558, Japan
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Ginowan-shi, 901-2725, Japan
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Hanyu-shi, 348-8505, Japan
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Hiroshima, 734-8530, Japan
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Hiroshima, 734-8551, Japan
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Hitachi-shi, 317-0077, Japan
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Isehara-shi, 259-1193, Japan
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Izumisano, 598-8577, Japan
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Izumo-shi, 693-8501, Japan
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Kamakura-shi, 247-8533, Japan
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Kamogawa-shi, 296-8602, Japan
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Kanazawa, 920-8641, Japan
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Kanazawa, 920-8650, Japan
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Kasuga-shi, 816-0864, Japan
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Kawasaki-shi, 216-8511, Japan
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COMPLETED

Koshigaya-shi, 343-8555, Japan
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COMPLETED

Kumagaya-shi, 360-0197, Japan
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Kumamoto, 860-0008, Japan
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Kusatsu-shi, 525-8585, Japan
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Kyoto, 602-8566, Japan
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Kyoto, 612-8555, Japan
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Maebashi, 371-0811, Japan
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Meguro-ku, 152-8902, Japan
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RECRUITING

Mitaka-shi, 181-8611, Japan
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Nagoya, 466-8560, Japan
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RECRUITING

Nerima-ku, 179-0072, Japan
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WITHDRAWN

Okayama, 702-8055, Japan
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Okazaki-shi, 444-0827, Japan
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RECRUITING

Omuta-shi, 837-0911, Japan
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Osaka, 534-0021, Japan
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Osaka, 543-0035, Japan
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Osaka, 545-8586, Japan
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COMPLETED

Sapporo, 062-0931, Japan
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Sapporo, 063-0005, Japan
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Shinagawa-ku, 142-8666, Japan
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Shinjuku-ku, 162-8655, Japan
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Suita-shi, 565-0871, Japan
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Tachikawa-shi, 190-8531, Japan
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Takamatsu, 760-0018, Japan
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Urasoe-shi, 901-2132, Japan
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Ureshino-shi, 843-0393, Japan
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Yokohama, 236-0004, Japan
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Yokohama, 241-0811, Japan
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Yokohama, 245-8575, Japan
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Kota Kinabalu, 88200, Malaysia
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuala Terengganu, 20400, Malaysia
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Kuantan, 25200, Malaysia
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Kubang Kerian, 16150, Malaysia
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Malacca, 75400, Malaysia
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Petaling Jaya, 47500, Malaysia
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Pulau Pinang, 10450, Malaysia
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Sarawak Miri, 98000, Malaysia
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Selangor Darul Ehsan, 42300, Malaysia
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Shah Alam, 40000, Malaysia
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Aguascalientes, 20259, Mexico
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Guadalajara, 44280, Mexico
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Guadalajara, 44340, Mexico
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Mexico City, 06720, Mexico
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Mexico City, 06726, Mexico
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Monterrey, 64460, Mexico
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San Luis Potosí City, 78250, Mexico
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RECRUITING

Tlalpan, 14050, Mexico
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NOT_YET_RECRUITING

Tlalpan, 14080, Mexico
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WITHDRAWN

Xalapa, 91020, Mexico
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RECRUITING

Cusco, CUSCO 01, Peru
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El Agustino, LIMA 10, Peru
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Lima, 15074, Peru
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Lima, 15088, Peru
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WITHDRAWN

Lima, 15324, Peru
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RECRUITING

Lima, LIMA 01, Peru
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NOT_YET_RECRUITING

Lima, LIMA 11, Peru
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Lima, LIMA 1, Peru
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RECRUITING

Lima, LIMA 31, Peru
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WITHDRAWN

Piura, 05, Peru
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COMPLETED

Cebu, 6000, Philippines
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RECRUITING

Iloilo City, Philippines
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RECRUITING

Manila, 1000, Philippines
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WITHDRAWN

Quezon City, 1100, Philippines
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SUSPENDED

Quezon City, 1109, Philippines
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RECRUITING

Chrzanów, 32-500, Poland
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TERMINATED

Lodz, 91-347, Poland
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WITHDRAWN

Rzeszów, 35-241, Poland
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WITHDRAWN

Warsaw, 00-416, Poland
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RECRUITING

Warsaw, 01-138, Poland
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RECRUITING

Warsaw, 04-141, Poland
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Wroclaw, 51-149, Poland
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Łańcut, 37-100, Poland
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Łęczna, 21-010, Poland
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Bayamón, 00961, Puerto Rico
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WITHDRAWN

Bucharest, 010825, Romania
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COMPLETED

Bucharest, 21105, Romania
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COMPLETED

Cluj-Napoca, 400000, Romania
Research Site
COMPLETED

Constanța, 900709, Romania
Research Site
COMPLETED

Iași, 700116, Romania
Research Site
COMPLETED

Sibiu, 550245, Romania
Research Site
COMPLETED

Timișoara, 300310, Romania
Research Site
RECRUITING

Jeddah, 21423, Saudi Arabia
Research Site
RECRUITING

Riyadh, 11426, Saudi Arabia
Research Site
RECRUITING

Riyadh, 12231, Saudi Arabia
Research Site
RECRUITING

Riyadh, 12372, Saudi Arabia
Research Site
WITHDRAWN

Bratislava, 82606, Slovakia
Research Site
TERMINATED

Johannesburg, Soweto, 2013, South Africa
Research Site
RECRUITING

Observatory, 7925, South Africa
Research Site
RECRUITING

Parktown, 2193, South Africa
Research Site
TERMINATED

Westdene, 2092, South Africa
Research Site
WITHDRAWN

Daegu, 42415, South Korea
Research Site
WITHDRAWN

Jeonju, 54907, South Korea
Research Site
WITHDRAWN

Seoul, 143-729, South Korea
Research Site
COMPLETED

Barcelona, 08003, Spain
Research Site
WITHDRAWN

Barcelona, 08036, Spain
Research Site
COMPLETED

Madrid, 28034, Spain
Research Site
COMPLETED

Majadahonda, 28222, Spain
Research Site
COMPLETED

Málaga, 29010, Spain
Research Site
WITHDRAWN

Ourense, 32005, Spain
Research Site
COMPLETED

Palma de Mallorca, 07010, Spain
Research Site
COMPLETED

Pamplona, 31008, Spain
Research Site
COMPLETED

Santander, 39008, Spain
Research Site
COMPLETED

Valencia, 46010, Spain
Research Site
RECRUITING

Helsingborg, 25187, Sweden
Research Site
RECRUITING

Huddinge, 14157, Sweden
Research Site
RECRUITING

Lund, 22185, Sweden
Research Site
RECRUITING

Malmo, 20502, Sweden
Research Site
WITHDRAWN

Solna, 17176, Sweden
Research Site
RECRUITING

Stockholm, 11861, Sweden
Research Site
ACTIVE_NOT_RECRUITING

Stockholm, 18288, Sweden
Research Site
RECRUITING

Umeå, 90185, Sweden
Research Site
RECRUITING

Västerås, 72189, Sweden
Research Site
RECRUITING

Kaohsiung City, 80756, Taiwan
Research Site
RECRUITING

Kaohsiung City, 81362, Taiwan
Research Site
RECRUITING

Taichung, 40447, Taiwan
Research Site
WITHDRAWN

Taichung, 40705, Taiwan
Research Site
RECRUITING

Taipei, 0116, Taiwan
Research Site
TERMINATED

Taipei, 10002, Taiwan
Research Site
RECRUITING

Taipei, 112, Taiwan
Research Site
RECRUITING

Taoyuan, 330, Taiwan
Research Site
RECRUITING

Taoyuan District, 333, Taiwan
Research Site
RECRUITING

Bangkok, 10210, Thailand
Research Site
RECRUITING

Bangkok, 10400, Thailand
Research Site
RECRUITING

Bangkok, 10700, Thailand
Research Site
RECRUITING

Banphaeo, 74120, Thailand
Research Site
RECRUITING

Chiang Mai, 50200, Thailand
Research Site
RECRUITING

Khlong Luang, 12120, Thailand
Research Site
SUSPENDED

Khon Kaen, 40002, Thailand
Research Site
RECRUITING

Phutthamonthon, 73170, Thailand
Research Site
WITHDRAWN

Ubonratchathani, 34000, Thailand
Research Site
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Research Site
RECRUITING

Diyarbakır, 21280, Turkey (Türkiye)
Research Site
RECRUITING

Istanbul, 34010, Turkey (Türkiye)
Research Site
RECRUITING

Istanbul, 34069, Turkey (Türkiye)
Research Site
RECRUITING

Istanbul, 34303, Turkey (Türkiye)
Research Site
RECRUITING

Istanbul, 34899, Turkey (Türkiye)
Research Site
RECRUITING

Izmir, 35040, Turkey (Türkiye)
Research Site
RECRUITING

Izmir, 35110, Turkey (Türkiye)
Research Site
RECRUITING

İzmit, 41000, Turkey (Türkiye)
Research Site
RECRUITING

Malatya, 44280, Turkey (Türkiye)
Research Site
RECRUITING

Ortahisar, 61080, Turkey (Türkiye)
Research Site
RECRUITING

Bristol, BS105NB, United Kingdom
Research Site
RECRUITING

Dundee, DD1 9SY, United Kingdom
Research Site
COMPLETED

Glasgow, G4 0SF, United Kingdom
Research Site
WITHDRAWN

Glasgow, G51 4TF, United Kingdom
Research Site
RECRUITING

Hampshire, SO16 6YD, United Kingdom
Research Site
RECRUITING

Huddersfield, HD3 3EA, United Kingdom
Research Site
RECRUITING

Leeds, LS9 7TF, United Kingdom
Research Site
RECRUITING

Leicester, LE3 9QP, United Kingdom
Research Site
RECRUITING

London, W1T 7HA, United Kingdom
Research Site
RECRUITING

London, W2 1NY, United Kingdom
Research Site
WITHDRAWN

London, W6 8RF, United Kingdom
Research Site
RECRUITING

Oxford, OX3 9DU, United Kingdom
Research Site
RECRUITING

Prescot, L35 5DR, United Kingdom
Research Site
RECRUITING

Tyne and Wear, NE29 8NH, United Kingdom
Research Site
WITHDRAWN

Wythenshawe, M23 9LT, United Kingdom
Research Site
RECRUITING

Haiphong, 180000, Vietnam
Research Site
WITHDRAWN

Haiphong, 180000, Vietnam
Research Site
RECRUITING

Hanoi, 100000, Vietnam
Research Site
RECRUITING

Hanoi, 10000, Vietnam
Research Site
WITHDRAWN

Ho Chi Minh City, 700000, Vietnam
Research Site
RECRUITING

Ho Chi Minh City, 700000, Vietnam
Research Site
NOT_YET_RECRUITING

Ho Chi Minh City, 700000, Vietnam
Research Site
WITHDRAWN

Ho Chi Minh City, Vietnam
Research Site
RECRUITING

Hochiminh City, 700000, Vietnam
Research Site
RECRUITING

Huế, 530000, Vietnam

Conditions

Explore the condition pages connected to this study.

VIRAL LUNG INFECTION AND ACUTE RESPIRATORY FAILURE