New hope for kids with rare, recurrent blood cell disorder

NCT ID NCT05828069

Summary

This study is testing an oral medication called tovorafenib (DAY101) in children and young adults with Langerhans cell histiocytosis (LCH) that has come back or hasn't responded to previous treatments. LCH is a rare disorder where too many immune cells build up and can damage bones, skin, and organs. The goal is to see if this weekly pill can safely control the disease by blocking signals that help these abnormal cells grow.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Albany Medical Center

    RECRUITING

    Albany, New York, 12208, United States

    Contact

    Contact Phone: •••-•••-••••

  • Alfred I duPont Hospital for Children

    RECRUITING

    Wilmington, Delaware, 19803, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    RECRUITING

    Las Vegas, Nevada, 89135, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Arkansas Children's Hospital

    RECRUITING

    Little Rock, Arkansas, 72202-3591, United States

    Contact

    Contact Phone: •••-•••-••••

  • Arnold Palmer Hospital for Children

    RECRUITING

    Orlando, Florida, 32806, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • BI-LO Charities Children's Cancer Center

    RECRUITING

    Greenville, South Carolina, 29605, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    SUSPENDED

    Houston, Texas, 77030, United States

  • Blank Children's Hospital

    RECRUITING

    Des Moines, Iowa, 50309, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • British Columbia Children's Hospital

    RECRUITING

    Vancouver, British Columbia, V6H 3V4, Canada

    Contact

    Contact Phone: •••-•••-••••

  • Bronson Methodist Hospital

    RECRUITING

    Kalamazoo, Michigan, 49007, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    RECRUITING

    Québec, G1V 4G2, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cardinal Glennon Children's Medical Center

    RECRUITING

    St Louis, Missouri, 63104, United States

    Contact Phone: •••-•••-••••

    Contact

  • Centre Hospitalier Universitaire Sainte-Justine

    RECRUITING

    Montreal, Quebec, H3T 1C5, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

    RECRUITING

    Sherbrooke, Quebec, J1H 5N4, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    RECRUITING

    Atlanta, Georgia, 30329, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital

    RECRUITING

    London, Ontario, N6A 5W9, Canada

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Children's Hospital Los Angeles

    RECRUITING

    Los Angeles, California, 90027, United States

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital New Orleans

    RECRUITING

    New Orleans, Louisiana, 70118, United States

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital and Medical Center of Omaha

    RECRUITING

    Omaha, Nebraska, 68114, United States

    Contact

    Contact Phone: •••-•••-••••

  • Children's Hospital of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Orange County

    RECRUITING

    Orange, California, 92868, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Pittsburgh of UPMC

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of San Antonio

    RECRUITING

    San Antonio, Texas, 78207, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of The King's Daughters

    RECRUITING

    Norfolk, Virginia, 23507, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospital of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    RECRUITING

    Minneapolis, Minnesota, 55404, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Connecticut Children's Medical Center

    RECRUITING

    Hartford, Connecticut, 06106, United States

    Contact

    Contact Phone: •••-•••-••••

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dayton Children's Hospital

    RECRUITING

    Dayton, Ohio, 45404, United States

    Contact

    Contact Phone: •••-•••-••••

  • Dell Children's Medical Center of Central Texas

    RECRUITING

    Austin, Texas, 78723, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact

    Contact Phone: •••-•••-••••

  • East Carolina University

    RECRUITING

    Greenville, North Carolina, 27834, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • East Tennessee Childrens Hospital

    RECRUITING

    Knoxville, Tennessee, 37916, United States

    Contact Phone: •••-•••-••••

    Contact

  • El Paso Children's Hospital

    RECRUITING

    El Paso, Texas, 79905, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Geisinger Medical Center

    RECRUITING

    Danville, Pennsylvania, 17822, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Golisano Children's Hospital of Southwest Florida

    RECRUITING

    Fort Myers, Florida, 33908, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

    Contact

    Contact Phone: •••-•••-••••

  • Hospital for Sick Children

    RECRUITING

    Toronto, Ontario, M5G 1X8, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • IWK Health Centre

    RECRUITING

    Halifax, Nova Scotia, B3K 6R8, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Kaiser Permanente Downey Medical Center

    RECRUITING

    Downey, California, 90242, United States

    Contact

    Contact Phone: •••-•••-••••

  • Kaiser Permanente-Oakland

    RECRUITING

    Oakland, California, 94611, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    RECRUITING

    New York, New York, 10016, United States

    Contact

    Contact Email: •••••@•••••

  • Loma Linda University Medical Center

    RECRUITING

    Loma Linda, California, 92354, United States

    Contact

    Contact Phone: •••-•••-••••

  • Lucile Packard Children's Hospital Stanford University

    RECRUITING

    Palo Alto, California, 94304, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lurie Children's Hospital-Chicago

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact

    Contact Phone: •••-•••-••••

  • M D Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Maimonides Medical Center

    RECRUITING

    Brooklyn, New York, 11219, United States

    Contact

    Contact Phone: •••-•••-••••

  • McMaster Children's Hospital at Hamilton Health Sciences

    RECRUITING

    Hamilton, Ontario, L8N 3Z5, Canada

    Contact Phone: •••-•••-••••

    Contact

  • Memorial Health University Medical Center

    RECRUITING

    Savannah, Georgia, 31404, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    RECRUITING

    Hollywood, Florida, 33021, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact

    Contact Phone: •••-•••-••••

  • Mercy Hospital Saint Louis

    RECRUITING

    St Louis, Missouri, 63141, United States

    Contact

    Contact Phone: •••-•••-••••

  • Methodist Children's Hospital of South Texas

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Michigan State University

    SUSPENDED

    East Lansing, Michigan, 48823, United States

  • Mission Hospital

    RECRUITING

    Asheville, North Carolina, 28801, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Montefiore Medical Center - Moses Campus

    RECRUITING

    The Bronx, New York, 10467, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mount Sinai Hospital

    RECRUITING

    New York, New York, 10029, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    RECRUITING

    New York, New York, 10032, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • NYP/Weill Cornell Medical Center

    RECRUITING

    New York, New York, 10065, United States

    Contact

    Contact Phone: •••-•••-••••

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nemours Children's Clinic - Pensacola

    RECRUITING

    Pensacola, Florida, 32504, United States

    Contact

    Contact Email: •••••@•••••

  • Nemours Children's Clinic-Jacksonville

    RECRUITING

    Jacksonville, Florida, 32207, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Nemours Children's Hospital

    RECRUITING

    Orlando, Florida, 32827, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • New York Medical College

    RECRUITING

    Valhalla, New York, 10595, United States

    Contact

    Contact Phone: •••-•••-••••

  • Nicklaus Children's Hospital

    RECRUITING

    Miami, Florida, 33155, United States

    Contact

    Contact Phone: •••-•••-••••

  • Ochsner Medical Center Jefferson

    RECRUITING

    New Orleans, Louisiana, 70121, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Oregon Health and Science University

    RECRUITING

    Portland, Oregon, 97239, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Perth Children's Hospital

    RECRUITING

    Perth, Western Australia, 6009, Australia

    Contact

    Contact Email: •••••@•••••

  • Primary Children's Hospital

    RECRUITING

    Salt Lake City, Utah, 84113, United States

    Contact Phone: •••-•••-••••

    Contact

  • Prisma Health Richland Hospital

    RECRUITING

    Columbia, South Carolina, 29203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Providence Sacred Heart Medical Center and Children's Hospital

    RECRUITING

    Spokane, Washington, 99204, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Queensland Children's Hospital

    RECRUITING

    South Brisbane, Queensland, 4101, Australia

    Contact Phone: •••-•••-••••

    Contact

  • Rainbow Babies and Childrens Hospital

    RECRUITING

    Cleveland, Ohio, 44106, United States

    Contact

    Contact Phone: •••-•••-••••

  • Riley Hospital for Children

    RECRUITING

    Indianapolis, Indiana, 46202, United States

    Contact

    Contact Phone: •••-•••-••••

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    RECRUITING

    Denver, Colorado, 80218, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Royal Children's Hospital

    RECRUITING

    Parkville, Victoria, 3052, Australia

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    RECRUITING

    New Brunswick, New Jersey, 08903, United States

    Contact

    Contact Phone: •••-•••-••••

  • Saint Christopher's Hospital for Children

    RECRUITING

    Philadelphia, Pennsylvania, 19134, United States

    Contact

    Contact Phone: •••-•••-••••

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    RECRUITING

    Tampa, Florida, 33607, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saint Joseph's Regional Medical Center

    RECRUITING

    Paterson, New Jersey, 07503, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saint Jude Midwest Affiliate

    RECRUITING

    Peoria, Illinois, 61637, United States

    Contact

    Contact Phone: •••-•••-••••

  • Scott and White Memorial Hospital

    RECRUITING

    Temple, Texas, 76508, United States

    Contact

    Contact Phone: •••-•••-••••

  • Seattle Children's Hospital

    RECRUITING

    Seattle, Washington, 98105, United States

    Contact

    Contact Phone: •••-•••-••••

  • Sinai Hospital of Baltimore

    RECRUITING

    Baltimore, Maryland, 21215, United States

    Contact

    Contact Phone: •••-•••-••••

  • State University of New York Upstate Medical University

    RECRUITING

    Syracuse, New York, 13210, United States

    Contact

    Contact Phone: •••-•••-••••

  • Summerlin Hospital Medical Center

    RECRUITING

    Las Vegas, Nevada, 89144, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sydney Children's Hospital

    RECRUITING

    Randwick, New South Wales, 2031, Australia

    Contact

    Contact Phone: •••-•••-••••

  • The Children's Hospital at TriStar Centennial

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

    Contact Phone: •••-•••-••••

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    RECRUITING

    New Hyde Park, New York, 11040, United States

    Contact

    Contact Phone: •••-•••-••••

  • UCSF Benioff Children's Hospital Oakland

    RECRUITING

    Oakland, California, 94609, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UCSF Medical Center-Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UF Health Cancer Institute - Gainesville

    RECRUITING

    Gainesville, Florida, 32610, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UT Southwestern/Simmons Cancer Center-Dallas

    RECRUITING

    Dallas, Texas, 75390, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Alberta Hospital

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Chicago Comprehensive Cancer Center

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Iowa/Holden Comprehensive Cancer Center

    RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Kentucky/Markey Cancer Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Phone: •••-•••-••••

    Contact

  • University of Minnesota/Masonic Cancer Center

    ACTIVE_NOT_RECRUITING

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    RECRUITING

    Jackson, Mississippi, 39216, United States

    Contact

    Contact Phone: •••-•••-••••

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Virginia Cancer Center

    RECRUITING

    Charlottesville, Virginia, 22908, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • VCU Massey Comprehensive Cancer Center

    RECRUITING

    Richmond, Virginia, 23298, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Valley Children's Hospital

    ACTIVE_NOT_RECRUITING

    Madera, California, 93636, United States

  • Vanderbilt University/Ingram Cancer Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

    Contact

    Contact Phone: •••-•••-••••

  • Wake Forest University Health Sciences

    RECRUITING

    Winston-Salem, North Carolina, 27157, United States

    Contact

    Contact Phone: •••-•••-••••

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West Virginia University Charleston Division

    RECRUITING

    Charleston, West Virginia, 25304, United States

    Contact

    Contact Phone: •••-•••-••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.