First pediatric trial tests new brain tumor drug after standard treatments fail
NCT ID NCT03429803
Summary
This study tested the safety and side effects of an experimental drug called Tovorafenib (DAY101) in children and young adults with recurrent low-grade brain tumors that didn't respond to standard treatments. Researchers wanted to find the highest dose children could tolerate without severe side effects. This was the first time this type of drug was given to children, and it targeted specific genetic changes found in these tumors.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Minnesota
Minneapolis, Minnesota, 55404, United States
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Children's National Hospital
Washington D.C., District of Columbia, 20010, United States
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Dana-Farber Cancer Institite
Boston, Massachusetts, 02215, United States
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Massacusetts General Hospital
Boston, Massachusetts, 02114, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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University of California, San Diego
San Diego, California, 92123, United States
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University of California, San Francisco
San Francisco, California, 94158, United States
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University of Florida
Gainesville, Florida, 32610, United States
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University of Utah
Salt Lake City, Utah, 84113, United States
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Washington University in St. Louis
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.