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Massive study tests if 3D mammograms find more breast cancers

NCT ID NCT03377036

Ongoing Diagnosis Sponsor: University Hospital Muenster Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large study compares two types of mammograms for breast cancer screening: a newer 3D method (digital breast tomosynthesis plus synthesized 2D images) and the standard 2D digital mammogram. About 100,000 women eligible for Germany's national screening program took part. The goal is to see if the 3D method detects more invasive breast cancers and reduces the number of cancers that appear between screenings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Digital breast tomosynthesis (3D mammography) plus synthesized 2D images
What this could lead to
If successful, this could show that 3D mammography detects more invasive breast cancers and reduces the number of cancers missed between screenings, potentially improving early detection.
What could go wrong
This is a screening comparison, not a treatment trial. Even if 3D mammography finds more cancers, it may also increase false alarms or overdiagnosis. Results may not apply to all populations or screening programs.

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Conditions

The condition(s) this trial relates to.

breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER SCREENING

Contacts and locations

Locations

  • Referenz-Screeening-Einheit Münster-Nord/Warendorf; Mammographie-Einheit Münster-Nord

    Münster, North Rhine-Westphalia, 48143, Germany

  • Referenz-Screening-Einheit Münster-Nord/Warendorf; Mammographie-Einheit Ahlen

    Ahlen, North Rhine-Westphalia, 59227, Germany

  • Screening-Einheit Aachen-Düren-Heinsberg; Mammographie-Einheit Aachen

    Aachen, North Rhine-Westphalia, 52062, Germany

  • Screening-Einheit Bielefeld, Gütersloh; Mammographie-Einheit Bielefeld

    Bielefeld, North Rhine-Westphalia, 33062, Germany

  • Screening-Einheit Duisburg; Mammographie-Einheit Duisburg

    Duisburg, North Rhine-Westphalia, 47057, Germany

  • Screening-Einheit Gelsenkirchen, Kreis Recklinghausen, Bottrop; Mammographie-Einheit Gelsenkirchen

    Gelsenkirchen, North Rhine-Westphalia, 45894, Germany

  • Screening-Einheit Hannover; Mammographie-Einheit Hannover

    Hanover, Lower Saxony, 30449, Germany

  • Screening-Einheit Höxter, Paderborn, Soest; Mammographie-Einheit Lippstadt

    Lippstadt, North Rhine-Westphalia, 59555, Germany

  • Screening-Einheit Höxter, Paderborn, Soest; Mammographie-Einheit Paderborn

    Paderborn, North Rhine-Westphalia, 33098, Germany

  • Screening-Einheit Köln rechtsrheinisch, Leverkusen, Rhein.-Berg. Kreis, Oberbergischer Kreis; Mammographie-Einheit Bergisch Gladbach

    Bergisch Gladbach, North Rhine-Westphalia, 51429, Germany

  • Screening-Einheit Minden-Lübbecke, Herford; Mammographie-Einheit Herford

    Herford, North Rhine-Westphalia, 32052, Germany

  • Screening-Einheit Märkischer Kreis, Hamm, Unna; Mammographie-Einheit Schwerte

    Schwerte, North Rhine-Westphalia, 58239, Germany

  • Screening-Einheit Mönchengladbach, Krefeld, Viersen; Mammographie-Einheit Krefeld

    Krefeld, North Rhine-Westphalia, 47805, Germany

  • Screening-Einheit Münster-Süd; Mammographie-Einheit Coesfeld

    Coesfeld, North Rhine-Westphalia, 48653, Germany

  • Screening-Einheit Münster-Süd; Mammographie-Einheit Münster

    Münster, North Rhine-Westphalia, 48153, Germany

  • Screening-Einheit Niedersachsen Mitte; Mammographie-Einheit Vechta

    Vechta, Lower Saxony, 49377, Germany

  • Screening-Einheit Niedersachsen Nord; Mammographie-Einheit Stade

    Stade, Lower Saxony, 21680, Germany

  • Screening-Einheit Niedersachsen Nordost; Mammographie-Einheit Lüneburg

    Lüneburg, Lower Saxony, 21337, Germany

  • Screening-Einheit Niedersachsen Nordwest; Mammographie-Einheit Wilhelmshaven

    Wilhelmshaven, Lower Saxony, 26382, Germany

  • Screening-Einheit Raum Bergisch Land/Kreis Mettmann; Mammographie-Einheit Solingen-Mitte

    Solingen, North Rhine-Westphalia, 42651, Germany

  • Screening-Einheit Raum Bergisch Land/Kreis Mettmann; Mammographie-Einheit Wuppertal-Elberfeld

    Wuppertal, North Rhine-Westphalia, 42109, Germany

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