Brain cancer chemo delivered directly: a safety first

NCT ID NCT03154996

First seen May 08, 2026 · Last updated Jun 16, 2026 · Updated 4 times

Summary

This early-stage study tested whether it is safe to deliver the chemotherapy drug topotecan directly into the brain over several days for people with recurrent high-grade gliomas (a type of aggressive brain cancer). Five participants received the treatment through a special infusion system. The main goal was to find a dose that causes only mild side effects, while also checking if the drug reaches the tumor and shrinks it.

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Contacts and locations

Locations

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

Conditions

Explore the condition pages connected to this study.