Could a daily dab of sirolimus ease tongue cysts?
NCT ID NCT04128722
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a sirolimus solution applied once daily to the tongue in 12 children and adults with mild to moderate lymphatic malformations. The goal was to see if it reduces severity of symptoms like oozing, bleeding, and pain over 12 weeks compared to no treatment. Researchers used expert ratings of photos to measure improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sirolimus (topical solution)
What this could lead to
If it works, this could offer a simple, non-invasive treatment option for tongue lymphatic malformations, reducing oozing, bleeding, and pain without the need for systemic drugs.
What could go wrong
This is a small, early-phase trial with only 12 participants, so results may not apply to everyone. The treatment may not improve symptoms significantly, and side effects from topical use are not yet well understood.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital NECKER -AP-HP - Dermatology
Paris, 75015, France
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Univsersity of TOURS _ Service de Dermatologie
Tours, Indre et Loire, 37044, France