Cream shows promise for rare skin condition, but study halted early

NCT ID NCT03363763

First seen Dec 18, 2025 · Last updated May 15, 2026 · Updated 17 times

Summary

This study tested a sirolimus cream applied daily for 12 weeks to treat facial angiofibromas (benign skin growths) in children with tuberous sclerosis complex. The trial aimed to see if the cream could safely reduce redness and lesion size. However, the study was terminated early, so results are limited.

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Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Children's Clinical Research Organization, Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Healthcare of Atlanta

    Atlanta, Georgia, 30329, United States

  • Children's Hospital of Fudan University

    Shanghai, 201102, China

  • Children's Hospital of Los Angeles, Division of Neurology

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • LeBonheur Children's Hospital

    Memphis, Tennessee, 38103, United States

  • Translational Genomics Research

    Phoenix, Arizona, 85004, United States

Conditions

Explore the condition pages connected to this study.