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Numbing spray may skew voice tests in reflux patients

NCT ID NCT07696429

Knowledge-focused Sponsor: Mario Bilić Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study investigates whether a topical numbing spray (lidocaine) affects voice recordings during high-speed laryngoscopy in adults with laryngopharyngeal reflux (LPR). Participants receive either lidocaine spray or a placebo on two separate days, and researchers compare voice parameters like vocal fold movement and sound quality. The goal is to determine if anesthesia alters the results, which could improve how voice exams are interpreted in LPR patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lidocaine 10% Spray
What this could lead to
If it works, this could help doctors understand whether numbing spray alters voice measurements, leading to more accurate laryngoscopy results.
What could go wrong
This is a small, early-stage study focused on measurement, not treatment. Results may not apply to other populations or voice conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

70 people

The number who actually took part.

Started

Mar 2019

Finished

Dec 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Newly diagnosed laryngopharyngeal reflux (LPR), defined as Reflux Symptom Index (RSI) \>13 and Reflux Finding Score (RFS) \>7 Age 18-45 years No prior HSDI recording Ability to tolerate HSDI examination without topical anesthesia Exclusion Criteria: * Known allergy to lidocaine and/or other allergens Acute respiratory infection within the preceding month Current smokers or regular alcohol consumers Chronic rhinosinusitis Prior surgery and/or radiotherapy of the larynx, neck, or thyroid gland Inability to visualize the full length of the vocal folds during the 2-second HSDI recording for anatomical reasons

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Conditions

The condition(s) this trial relates to.

Laryngopharyngeal Reflux

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laryngo-pharyngeal reflux

Contacts and locations

Locations

  • University Hospital Centre Zagreb (KBC Zagreb), Department of ORL Head and Neck Surgery

    Zagreb, 10000, Croatia

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