Lymphoma drug trial halted after researchers fail to find safe dose
NCT ID NCT05403450
Summary
This study aimed to test the safety and find the right dose of a new drug combination (tolinapant plus oral decitabine/cedazuridine) for adults with a rare and aggressive blood cancer that had returned or stopped responding to prior treatments. The trial was stopped early after the initial phase because researchers could not identify a dose that was both safe and tolerable for patients. Therefore, the planned second phase to test how well the combination worked was not conducted.
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Contacts and locations
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Locations
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AP-HP Pitie Saltpetriere Site# 552
Paris, 75013, France
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Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia Site#650
Brescia, 25123, Italy
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Barbara Ann Karmanos Cancer Institute Site#159
Detroit, Michigan, 48201, United States
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CHU Saint-Eloi Site#556
Montpellier, 34295, France
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Centre Antoine Lacassagne
Nice, 06189, France
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Centre Henri Becquerel
Rouen, Seine-Maritime, 76038, France
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City of Hope Site #151
Duarte, California, 91010, United States
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Concord Hospital
Concord, New South Wales, 2139, Australia
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Fondazione IRCCS San Gerardo dei Tintori Site #655
Monza, 20900, Italy
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Guy's and Saint Thomas' NHS Foundation Trust
London, England, SE1 9Rt, United Kingdom
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Hospital Universitario 12 de Octubre Site#710
Madrid, 28041, Spain
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Hospital Universitario Fundación Jiménez Díaz Site #703
Madrid, 28040, Spain
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Hospital Universitario Marqués de Valdecilla Site#711
Santander, 39008, Spain
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Hospital Universitario Virgen del Rocío
Seville, Andalusia, 41013, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, Catalonia, 8025, Spain
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Hospital del Mar Site #704
Barcelona, 08003, Spain
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Hôpital Bretonneau
Tours, Indre-et-Loire, 37000, France
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Institut Bergonié Site#553
Bordeaux, 33000, France
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Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
Barcelona, Catalonia, 8908, Spain
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Institut Gustave Roussy
Villejuif, 94805, France
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Institut Paoli-Calmettes
Marseille, 13009, France
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Istituto Europeo di Oncologia Site#652
Milan, 20141, Italy
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Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
Meldola, Forli-Cesena, 47014, Italy
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Linear Clinical Research Site #834
Nedlands, 6009, Australia
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Moffitt Cancer Center Site #157
Tampa, Florida, 33612, United States
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Monash Medical Center
Melbourne, Victoria, 3168, Australia
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NYU Langone Laura and Isaac Perlmutter Cancer Center Site #153
New York, New York, 10016, United States
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
Warsaw, Masovia, 02-781, Poland
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Ospedale Santa Maria delle Croci di Ravenna
Ravenna, Emilia-Romagna, 48121, Italy
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Ośrodek Badań Klinicznych Wczesnych Faz - Uniwersyteckie Centrum Kliniczne w Gdańsku
Gdansk, Pomeranian Voivodeship, 80-214, Poland
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Rochester Skin Lymphoma Medical Group, PLLC Site #147
Fairport, New York, 14450, United States
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Stanford University
Stanford, California, 94305, United States
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The Christie NHS Foundation Trust
Manchester, England, M20 4BX, United Kingdom
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The University of Texas MD Anderson Cancer Center Site #101
Houston, Texas, 77030, United States
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U.O.C. di Ematologia Pad. 8IRCCS Azienda OspedalieroUniversitaria di Bologna Site#651
Bologna, 40138, Italy
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University College London Hospitals NHS Foundation Trust
London, England, W1T 7HA, United Kingdom
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University of Califonia, Los Angeles
Los Angeles, California, 90095, United States
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University of Colorado Anschutz Medical Campus Site #118
Aurora, Colorado, 80045, United States
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University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109, United States
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University of Pennsylvania Site# 160
Philadelphia, Pennsylvania, 19104, United States
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University of Virginia Comprehensive Cancer Center
Charlottesville, Virginia, 22908, United States
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Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322, United States
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Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi
Lodz, Łódź Voivodeship, 93-513, Poland
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Yale Cancer Center Site #109
New Haven, Connecticut, 06511, United States
Conditions
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