New triple therapy targets hard-to-treat belly fluid in advanced cancer patients

NCT ID NCT07196540

First seen Oct 31, 2025 · Last updated Apr 29, 2026 · Updated 25 times

Summary

This study tests a new treatment for people with advanced digestive tract cancers that cause fluid buildup in the belly (malignant ascites) after standard treatments have stopped working. The treatment combines a modified protein (rmhTNF-NC) injected into the belly, an immunotherapy drug (tislelizumab), and targeted radiation. The goal is to see if this combination can shrink or eliminate the fluid and improve outcomes. About 78 adults will take part.

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