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Magnetic pulses to the brain may restore vision in adult lazy eye

NCT ID NCT05393739

Disease control Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called theta burst transcranial magnetic stimulation (TBS) can improve vision in adults with amblyopia, or lazy eye. Amblyopia affects about 3% of adults and currently has no effective treatment after childhood. Researchers will compare three types of TBS (intermittent, continuous, and sham) in 30 adults aged 20–50, measuring changes in visual acuity shortly after treatment and two weeks later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
theta burst transcranial magnetic stimulation (TBS) procedure
What this could lead to
If it works, this could point toward a non-invasive treatment to improve vision in adults with amblyopia, for whom no effective therapy currently exists.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply broadly. The effects may be temporary or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult amblyopia participants, aged 20-50 years old. 2. Based on inclusion criteria, there was a minimum of 2 lines difference in BCVA between the 2 eyes. 3. An amblyogenic factor and history of amblyopia treatment was recorded Exclusion Criteria: 1. Unstable vital sign 2. History of brain injury and/or head trauma 3. Neurological and psychiatric disease 4. Seizures or family history of seizure 5. Pregnancy 6. Uncontrolled migraine or the presence of metallic implants or shunt in the head or torso 7. Wide region of ischemic cicatrix, multiple sclerosis, taking tricycle antidepressants, 8. Analgesics or any drugs may decrease the threshold for inducing seizure 9. Experienced sleep disorders during the rTMS treatment 10. Severe alcoholism or taking seizure drugs 11. Severe heart diseases or uncontrollable migraine caused by high intracranial pressure

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Conditions

The condition(s) this trial relates to.

amblyopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amblyopia

Contacts and locations

Locations

  • National Taiwan University Hospital

    Taipei County, 100225, Taiwan

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