Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can pregnancy hormones worsen jaw pain? a study tracks the link

NCT ID NCT07791173

Knowledge-focused Sponsor: Zeynep Serra Kalkan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

Researchers are following 60 pregnant women to see how jaw joint and muscle pain, known as temporomandibular disorders (TMD), change from early to late pregnancy. At two visits, one in the first trimester and one in the third, they will measure jaw function, pain levels, and blood markers of inflammation and hormones. The goal is to understand whether hormonal and inflammatory shifts during pregnancy are linked to the start or worsening of TMD symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
No drug or device is tested. The study observes jaw function, pain, and blood markers across pregnancy.
What this could lead to
If it works, this could clarify how pregnancy hormones and inflammation affect jaw pain, pointing toward better ways to prevent or manage TMD in pregnant women.
What could go wrong
This is a small observational study with 60 participants, so results may not apply to all pregnant women. It measures associations, not proof of cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women aged 18-40 years presenting to the Obstetrics and Gynecology outpatient clinic during their first trimester, recruited consecutively based on eligibility criteria.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18-40 years * Singleton, healthy pregnancy * Presenting to the Obstetrics and Gynecology outpatient clinic during the first trimester (weeks 8-12) * No history of systemic rheumatic disease, chronic pain syndrome, or serious psychiatric illness * No prior orthodontic treatment * Written informed consent after being informed about the purpose and scope of the study Exclusion Criteria: * Prior treatment for temporomandibular disorders (splint, botulinum toxin, surgery, etc.) * History of maxillofacial trauma or temporomandibular joint surgery * Systemic rheumatic disease, connective tissue disease, or chronic pain syndrome * Use of systemic corticosteroids or hormone replacement therapy * Pregnancy achieved through assisted reproductive techniques (e.g., IVF) * Refusal to consent to blood sampling or questionnaire administration * Language barrier preventing understanding and completion of Turkish-language questionnaires

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Pregnancy are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Chronic Pain temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pregnancy Temporomandibular disorders (TMD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital

    Bursa, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.