New blood test could speed up Life-Saving treatment for HUS patients

NCT ID NCT04777435

Completed Diagnosis Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new blood test designed to quickly determine whether the complement system is involved in a serious kidney condition called thrombotic microangiopathy (TMA). The test measures complement deposits on cells in a lab sample. Researchers compared test results to how patients actually responded to treatment. The goal is to help doctors decide sooner whether to use a powerful drug called Eculizumab. The study involved 100 participants and has already been completed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Therapeutic orientation test (blood test measuring complement deposits on endothelial cells)
What this could lead to: If successful, this test could help doctors quickly identify which patients with HUS need complement-blocking therapy, potentially improving treatment timing and outcomes.
What could go wrong: This is a small, completed diagnostic study (100 participants) that measures test accuracy against clinical judgment. The test may not be widely adopted or may not perform as well in larger, more diverse populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

disease Hemolysis thrombotic microangiopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THROMBOTIC MICRO-ANGIOPATHY

Contacts and locations

Locations

APHM-Hôpital de la Conception

Marseille, France
APHP-Hôpital Tenon

Paris, France
CH de Perpignan

Perpignan, France
CHRU Tours

Tours, France
CHU de Bordeaux

Bordeaux, France
CHU de Grenoble

Grenoble, France
CHU de Lille

Lille, France
CHU de Limoges

Limoges, France
CHU de Nantes

Nantes, France
CHU de Nice

Nice, France
CHU de Nîmes

Nîmes, France
CHU de Poitiers

Poitiers, France
CHU de Rouen

Rouen, France
CHU de Toulouse

Toulouse, France
Centre Nephrocare Castelnau-le-Lez

Castelnau-le-Lez, France
HPGN- Narbonne

Narbonne, France
Hôpital Paris Necker

Paris, France
Hôpitaux Universitaires de Strasbourg

Strasbourg, France
Montpellier University Hospital

Montpellier, France
Site Médipôle Cabestany

Cabestany, France