Immunotherapy before surgery shows promise for genetic subtype of colon cancer

NCT ID NCT05116085

First seen Feb 16, 2026 · Last updated May 16, 2026 · Updated 11 times

Summary

This study tested the drug tislelizumab given before surgery in 33 people with early-stage (stage II-III) colorectal cancer that has specific genetic changes (MSI-H or dMMR). The goal was to see if the drug could shrink or eliminate the tumor before surgical removal. The main measure was how many patients had most of their cancer cells killed by the treatment.

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Contacts and locations

Locations

  • Hubei Cancer Hospital

    Wuhan, Hubei, 430079, China

  • Liaoning Cancer Hospital and Institute

    Shenyang, Liaoning, 110042, China

  • Shandong Cancer Hospital

    Jinan, Shandong, 250117, China

  • Sun Yat Sen University Cancer Center

    Guangzhou, Guangdong, 510060, China

  • The Affiliated Hospital of Qingdao University Branch South

    Qingdao, Shandong, 266000, China

  • The First Affiliated Hospital of Bengbu Medical College

    Bengbu, Anhui, 233004, China

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310009, China

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, Tianjin Municipality, 300060, China

Conditions

Explore the condition pages connected to this study.